Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (<i>FTO</i>) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber inta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1793 |
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| author | Przemyslaw Czajkowski Edyta Adamska-Patruno Witold Bauer Urszula Krasowska Joanna Fiedorczuk Monika Moroz Maria Gorska Adam Kretowski |
| author_facet | Przemyslaw Czajkowski Edyta Adamska-Patruno Witold Bauer Urszula Krasowska Joanna Fiedorczuk Monika Moroz Maria Gorska Adam Kretowski |
| author_sort | Przemyslaw Czajkowski |
| collection | DOAJ |
| description | Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (<i>FTO</i>) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber intake on the obesity-related parameters and lipid profile in the Polish population. We selected 819 Polish Caucasian adult subjects (52.5% female and 47.5% male) for a final gene–diet interaction analysis, with mean BMI 28.5 (±6.6) kg/m<sup>2</sup>. We performed measurements of anthropometric parameters, total body fat content and distribution, and blood glucose, insulin, and lipid concentrations. Daily fiber intake was analyzed based on 3-day food-intake diaries, and daily physical activity was evaluated based on the International Physical Activity Questionnaire—Long Form. Our study shows that carriers of the GG genotype (rs3751812), CC genotype (rs8050136), and GG genotype (rs6499640) presented lower hip circumference if daily fiber intake was above 18 g per day. Additionally, GG genotype (rs3751812) and CC genotype (rs8050136) carriers showed surprisingly higher total cholesterol and LDL-cholesterol levels when they were stratified to the group with higher than median fiber intake. The results of this study highlight that high-fiber diets may positively affect anthropometric parameters but may also worsen lipid profile dependent on the <i>FTO</i> genotype. |
| first_indexed | 2024-03-10T05:45:13Z |
| format | Article |
| id | doaj.art-78a1d2efafa4476fb8cc61f7f4d56a60 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-78a1d2efafa4476fb8cc61f7f4d56a602023-11-22T22:13:47ZengMDPI AGAntioxidants2076-39212021-11-011011179310.3390/antiox10111793Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish OriginPrzemyslaw Czajkowski0Edyta Adamska-Patruno1Witold Bauer2Urszula Krasowska3Joanna Fiedorczuk4Monika Moroz5Maria Gorska6Adam Kretowski7Clinical Research Centre, Department of Nutriomics, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandClinical Research Centre, Department of Nutriomics, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandClinical Research Centre, Department of Nutriomics, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandClinical Research Centre, Department of Nutriomics, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandClinical Research Centre, Medical University of Bialystok Clinical Hospital, Marii Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandClinical Research Centre, Medical University of Bialystok Clinical Hospital, Marii Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandClinical Research Centre, Department of Nutriomics, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandGenetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (<i>FTO</i>) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber intake on the obesity-related parameters and lipid profile in the Polish population. We selected 819 Polish Caucasian adult subjects (52.5% female and 47.5% male) for a final gene–diet interaction analysis, with mean BMI 28.5 (±6.6) kg/m<sup>2</sup>. We performed measurements of anthropometric parameters, total body fat content and distribution, and blood glucose, insulin, and lipid concentrations. Daily fiber intake was analyzed based on 3-day food-intake diaries, and daily physical activity was evaluated based on the International Physical Activity Questionnaire—Long Form. Our study shows that carriers of the GG genotype (rs3751812), CC genotype (rs8050136), and GG genotype (rs6499640) presented lower hip circumference if daily fiber intake was above 18 g per day. Additionally, GG genotype (rs3751812) and CC genotype (rs8050136) carriers showed surprisingly higher total cholesterol and LDL-cholesterol levels when they were stratified to the group with higher than median fiber intake. The results of this study highlight that high-fiber diets may positively affect anthropometric parameters but may also worsen lipid profile dependent on the <i>FTO</i> genotype.https://www.mdpi.com/2076-3921/10/11/1793<i>FTO</i> genedietary fibergene–diet interactionglucose metabolismmacronutrientsobesity |
| spellingShingle | Przemyslaw Czajkowski Edyta Adamska-Patruno Witold Bauer Urszula Krasowska Joanna Fiedorczuk Monika Moroz Maria Gorska Adam Kretowski Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin Antioxidants <i>FTO</i> gene dietary fiber gene–diet interaction glucose metabolism macronutrients obesity |
| title | Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin |
| title_full | Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin |
| title_fullStr | Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin |
| title_full_unstemmed | Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin |
| title_short | Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin |
| title_sort | dietary fiber intake may influence the impact of i fto i genetic variants on obesity parameters and lipid profile a cohort study of a caucasian population of polish origin |
| topic | <i>FTO</i> gene dietary fiber gene–diet interaction glucose metabolism macronutrients obesity |
| url | https://www.mdpi.com/2076-3921/10/11/1793 |
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