The scene of lung pathology during PRRSV-1 infection
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. The disease was firstly reported in 1987 and became endemic in many countries. Since then, outbreaks caused by strains of high virulence have been report...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1330990/full |
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| author | Inés Ruedas-Torres Inés Ruedas-Torres José María Sánchez-Carvajal Francisco Javier Salguero Francisco José Pallarés Librado Carrasco Enric Mateu Jaime Gómez-Laguna Irene Magdalena Rodríguez-Gómez |
| author_facet | Inés Ruedas-Torres Inés Ruedas-Torres José María Sánchez-Carvajal Francisco Javier Salguero Francisco José Pallarés Librado Carrasco Enric Mateu Jaime Gómez-Laguna Irene Magdalena Rodríguez-Gómez |
| author_sort | Inés Ruedas-Torres |
| collection | DOAJ |
| description | Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. The disease was firstly reported in 1987 and became endemic in many countries. Since then, outbreaks caused by strains of high virulence have been reported several times in Asia, America and Europe. Interstitial pneumonia, microscopically characterised by thickened alveolar septa, is the hallmark lesion of PRRS. However, suppurative bronchopneumonia and proliferative and necrotising pneumonia are also observed, particularly when a virulent strain is involved. This raises the question of whether the infection by certain strains results in an overstimulation of the proinflammatory response and whether there is some degree of correlation between the strain involved and a particular pattern of lung injury. Thus, it is of interest to know how the inflammatory response is modulated in these cases due to the interplay between virus and host factors. This review provides an overview of the macroscopic, microscopic, and molecular pathology of PRRSV-1 strains in the lung, emphasising the differences between strains of different virulence. |
| first_indexed | 2024-04-24T22:40:32Z |
| format | Article |
| id | doaj.art-78a276fc98b04f799c1cdb8b64dc96ce |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-24T22:40:32Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-78a276fc98b04f799c1cdb8b64dc96ce2024-03-19T04:50:01ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-03-011110.3389/fvets.2024.13309901330990The scene of lung pathology during PRRSV-1 infectionInés Ruedas-Torres0Inés Ruedas-Torres1José María Sánchez-Carvajal2Francisco Javier Salguero3Francisco José Pallarés4Librado Carrasco5Enric Mateu6Jaime Gómez-Laguna7Irene Magdalena Rodríguez-Gómez8United Kingdom Health Security Agency (UKHSA Porton Down), Salisbury, United KingdomDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, International Agrifood Campus of Excellence (CeiA3), Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, International Agrifood Campus of Excellence (CeiA3), Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainUnited Kingdom Health Security Agency (UKHSA Porton Down), Salisbury, United KingdomDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, International Agrifood Campus of Excellence (CeiA3), Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, International Agrifood Campus of Excellence (CeiA3), Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainDepartment of Animal Health and Anatomy, Autonomous University of Barcelona, Barcelona, SpainDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, International Agrifood Campus of Excellence (CeiA3), Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, International Agrifood Campus of Excellence (CeiA3), Faculty of Veterinary Medicine, University of Córdoba, Córdoba, SpainPorcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. The disease was firstly reported in 1987 and became endemic in many countries. Since then, outbreaks caused by strains of high virulence have been reported several times in Asia, America and Europe. Interstitial pneumonia, microscopically characterised by thickened alveolar septa, is the hallmark lesion of PRRS. However, suppurative bronchopneumonia and proliferative and necrotising pneumonia are also observed, particularly when a virulent strain is involved. This raises the question of whether the infection by certain strains results in an overstimulation of the proinflammatory response and whether there is some degree of correlation between the strain involved and a particular pattern of lung injury. Thus, it is of interest to know how the inflammatory response is modulated in these cases due to the interplay between virus and host factors. This review provides an overview of the macroscopic, microscopic, and molecular pathology of PRRSV-1 strains in the lung, emphasising the differences between strains of different virulence.https://www.frontiersin.org/articles/10.3389/fvets.2024.1330990/fullPRRSV-1pathologylunginterstitial pneumoniabronchopneumoniainflammation |
| spellingShingle | Inés Ruedas-Torres Inés Ruedas-Torres José María Sánchez-Carvajal Francisco Javier Salguero Francisco José Pallarés Librado Carrasco Enric Mateu Jaime Gómez-Laguna Irene Magdalena Rodríguez-Gómez The scene of lung pathology during PRRSV-1 infection Frontiers in Veterinary Science PRRSV-1 pathology lung interstitial pneumonia bronchopneumonia inflammation |
| title | The scene of lung pathology during PRRSV-1 infection |
| title_full | The scene of lung pathology during PRRSV-1 infection |
| title_fullStr | The scene of lung pathology during PRRSV-1 infection |
| title_full_unstemmed | The scene of lung pathology during PRRSV-1 infection |
| title_short | The scene of lung pathology during PRRSV-1 infection |
| title_sort | scene of lung pathology during prrsv 1 infection |
| topic | PRRSV-1 pathology lung interstitial pneumonia bronchopneumonia inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1330990/full |
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