Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease
Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as the most reliable analytic parameter for monitoring t...
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| Format: | Article |
| Language: | English |
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Elsevier
2008-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015307942 |
| _version_ | 1818928888000020480 |
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| author | Masami Taniguchi Noritaka Higashi Emiko Ono Haruhisa Mita Kazuo Akiyama |
| author_facet | Masami Taniguchi Noritaka Higashi Emiko Ono Haruhisa Mita Kazuo Akiyama |
| author_sort | Masami Taniguchi |
| collection | DOAJ |
| description | Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as the most reliable analytic parameter for monitoring the endogenous synthesis of CysLTs. From recent studies on the U-LTE4 associated with adult stable asthma we identified four factors for hyperleukotrieneuria, namely, aspirin intolerance, eosinophilic nasal polyposis (ENP), vasculitis, and severe asthma. In ENP, there is prominent infiltration of eosinophils in the sinus and polyp tissues, which is linked to adult asthma and aspirin sensitivity, and ENP is the most important factor for the overproduction of CysLTs in asthmatics. We also demonstrated that anaphylaxis and eosinophilic pneumonia (EP) are associated with a marked increase in the U-LTE4 concentration. Under these disease conditions, U-LTE4 may be one of the candidate biomarkers. Moreover, the changes in U-LTE4 concentrations may provide valuable information concerning therapeutic targets. |
| first_indexed | 2024-12-20T03:36:03Z |
| format | Article |
| id | doaj.art-78a2ce7517ff4078be7004c725a47c32 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-20T03:36:03Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-78a2ce7517ff4078be7004c725a47c322022-12-21T19:54:53ZengElsevierAllergology International1323-89302008-01-0157431332010.2332/allergolint.08-RAI-0040Hyperleukotrieneuria in Patients with Allergic and Inflammatory DiseaseMasami Taniguchi0Noritaka Higashi1Emiko Ono2Haruhisa Mita3Kazuo Akiyama4Clinical Research Center, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.Clinical Research Center, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.Clinical Research Center, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.Clinical Research Center, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.Clinical Research Center, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as the most reliable analytic parameter for monitoring the endogenous synthesis of CysLTs. From recent studies on the U-LTE4 associated with adult stable asthma we identified four factors for hyperleukotrieneuria, namely, aspirin intolerance, eosinophilic nasal polyposis (ENP), vasculitis, and severe asthma. In ENP, there is prominent infiltration of eosinophils in the sinus and polyp tissues, which is linked to adult asthma and aspirin sensitivity, and ENP is the most important factor for the overproduction of CysLTs in asthmatics. We also demonstrated that anaphylaxis and eosinophilic pneumonia (EP) are associated with a marked increase in the U-LTE4 concentration. Under these disease conditions, U-LTE4 may be one of the candidate biomarkers. Moreover, the changes in U-LTE4 concentrations may provide valuable information concerning therapeutic targets.http://www.sciencedirect.com/science/article/pii/S1323893015307942anaphylaxisaspirin-intolerant asthma (AIA)Churg-Strauss syndrome (CSS)cysteinyl leukotrienes (CysLTs)nasal polyp |
| spellingShingle | Masami Taniguchi Noritaka Higashi Emiko Ono Haruhisa Mita Kazuo Akiyama Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease Allergology International anaphylaxis aspirin-intolerant asthma (AIA) Churg-Strauss syndrome (CSS) cysteinyl leukotrienes (CysLTs) nasal polyp |
| title | Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease |
| title_full | Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease |
| title_fullStr | Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease |
| title_full_unstemmed | Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease |
| title_short | Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease |
| title_sort | hyperleukotrieneuria in patients with allergic and inflammatory disease |
| topic | anaphylaxis aspirin-intolerant asthma (AIA) Churg-Strauss syndrome (CSS) cysteinyl leukotrienes (CysLTs) nasal polyp |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015307942 |
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