A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor
Abstract A 50‐year‐old Japanese woman with advanced breast cancer presented with productive cough and dyspnea while she was receiving a sixth cycle of chemotherapy including atezolizumab. Chest computed tomography revealed bronchiolitis and transbronchial lung cryobiopsy revealed eosinophilic bronch...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-07-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14931 |
| _version_ | 1797788534769188864 |
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| author | Akiko Tamura Masao Hashimoto Atsuko Hosoi Masayuki Hojo |
| author_facet | Akiko Tamura Masao Hashimoto Atsuko Hosoi Masayuki Hojo |
| author_sort | Akiko Tamura |
| collection | DOAJ |
| description | Abstract A 50‐year‐old Japanese woman with advanced breast cancer presented with productive cough and dyspnea while she was receiving a sixth cycle of chemotherapy including atezolizumab. Chest computed tomography revealed bronchiolitis and transbronchial lung cryobiopsy revealed eosinophilic bronchiolitis. Corticosteroid therapy successfully resolved her symptoms. Eosinophilic bronchiolitis is a rare but important immune‐related adverse event; herein, we discuss its diagnosis and possible pathophysiology. |
| first_indexed | 2024-03-13T01:37:54Z |
| format | Article |
| id | doaj.art-78a5db7ff5dd4cbfbdf347669e20730e |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-13T01:37:54Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-78a5db7ff5dd4cbfbdf347669e20730e2023-07-04T00:04:28ZengWileyThoracic Cancer1759-77061759-77142023-07-0114191894189810.1111/1759-7714.14931A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitorAkiko Tamura0Masao Hashimoto1Atsuko Hosoi2Masayuki Hojo3National Center for Global Health and Medicine Hospital, Respiratory Medicine Tokyo JapanNational Center for Global Health and Medicine Hospital, Respiratory Medicine Tokyo JapanNational Center for Global Health and Medicine Hospital, Pathology Tokyo JapanNational Center for Global Health and Medicine Hospital, Respiratory Medicine Tokyo JapanAbstract A 50‐year‐old Japanese woman with advanced breast cancer presented with productive cough and dyspnea while she was receiving a sixth cycle of chemotherapy including atezolizumab. Chest computed tomography revealed bronchiolitis and transbronchial lung cryobiopsy revealed eosinophilic bronchiolitis. Corticosteroid therapy successfully resolved her symptoms. Eosinophilic bronchiolitis is a rare but important immune‐related adverse event; herein, we discuss its diagnosis and possible pathophysiology.https://doi.org/10.1111/1759-7714.14931atezolizumabbronchiolitiseosinophilimmune checkpoint inhibitorimmune‐related adverse event |
| spellingShingle | Akiko Tamura Masao Hashimoto Atsuko Hosoi Masayuki Hojo A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor Thoracic Cancer atezolizumab bronchiolitis eosinophil immune checkpoint inhibitor immune‐related adverse event |
| title | A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor |
| title_full | A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor |
| title_fullStr | A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor |
| title_full_unstemmed | A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor |
| title_short | A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor |
| title_sort | case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor |
| topic | atezolizumab bronchiolitis eosinophil immune checkpoint inhibitor immune‐related adverse event |
| url | https://doi.org/10.1111/1759-7714.14931 |
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