Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT
Abstract Keratoacanthoma‐like squamous cell carcinoma (KA‐like SCC) is a malignant classification of KA. We report here a case of surgical combined with 5‐aminolevulinic acid‐photodynamic therapy (ALA‐PDT) to treat KA‐like SCC in an elderly male with successful tumor removal. The tumor resection was...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-03-01
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| Series: | Translational Biophotonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/tbio.202200005 |
| _version_ | 1797840482502443008 |
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| author | Jingjuan Shi Jia Yan Yutong Yang Jianhua Huang Minfeng Wu Xiuli Wang Hongwei Wang Lei Shi |
| author_facet | Jingjuan Shi Jia Yan Yutong Yang Jianhua Huang Minfeng Wu Xiuli Wang Hongwei Wang Lei Shi |
| author_sort | Jingjuan Shi |
| collection | DOAJ |
| description | Abstract Keratoacanthoma‐like squamous cell carcinoma (KA‐like SCC) is a malignant classification of KA. We report here a case of surgical combined with 5‐aminolevulinic acid‐photodynamic therapy (ALA‐PDT) to treat KA‐like SCC in an elderly male with successful tumor removal. The tumor resection was performed before ALA‐PDT. One week later, the lesion site was further treated with 20% ALA for 3 h when it was unknown whether the tumor was resected entirely or not. The irradiation was performed with a 633 nm light‐emitting diode lamp at 100 mW/cm2 for 200 J/cm2 after wiping off the ALA cream. Two sessions of ALA‐PDT were performed at a 2 weeks interval. One month after ALA‐PDT, the surgical trace of the lesion was found to have disappeared entirely, with a little scab, and the cancer did not recur. After 1 year of follow‐up, there was no recurrence. The combination with surgery and ALA‐PDT may provide a new idea for the treatment of KA‐like SCC for a wide range of patients. |
| first_indexed | 2024-04-09T16:16:03Z |
| format | Article |
| id | doaj.art-78a72f2a4a664204b8af3423dd44c0ea |
| institution | Directory Open Access Journal |
| issn | 2627-1850 |
| language | English |
| last_indexed | 2024-04-09T16:16:03Z |
| publishDate | 2023-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Translational Biophotonics |
| spelling | doaj.art-78a72f2a4a664204b8af3423dd44c0ea2023-04-24T05:21:43ZengWiley-VCHTranslational Biophotonics2627-18502023-03-0151n/an/a10.1002/tbio.202200005Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDTJingjuan Shi0Jia Yan1Yutong Yang2Jianhua Huang3Minfeng Wu4Xiuli Wang5Hongwei Wang6Lei Shi7Department of Dermatology, Huadong Hospital Fudan University Shanghai ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai ChinaDepartment of Dermatology, Huadong Hospital Fudan University Shanghai ChinaDepartment of Dermatology, Huadong Hospital Fudan University Shanghai ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai ChinaDepartment of Dermatology, Huadong Hospital Fudan University Shanghai ChinaAbstract Keratoacanthoma‐like squamous cell carcinoma (KA‐like SCC) is a malignant classification of KA. We report here a case of surgical combined with 5‐aminolevulinic acid‐photodynamic therapy (ALA‐PDT) to treat KA‐like SCC in an elderly male with successful tumor removal. The tumor resection was performed before ALA‐PDT. One week later, the lesion site was further treated with 20% ALA for 3 h when it was unknown whether the tumor was resected entirely or not. The irradiation was performed with a 633 nm light‐emitting diode lamp at 100 mW/cm2 for 200 J/cm2 after wiping off the ALA cream. Two sessions of ALA‐PDT were performed at a 2 weeks interval. One month after ALA‐PDT, the surgical trace of the lesion was found to have disappeared entirely, with a little scab, and the cancer did not recur. After 1 year of follow‐up, there was no recurrence. The combination with surgery and ALA‐PDT may provide a new idea for the treatment of KA‐like SCC for a wide range of patients.https://doi.org/10.1002/tbio.2022000055‐aminolevulinic acidALA‐PDTKA‐like SCCkeratoacanthoma |
| spellingShingle | Jingjuan Shi Jia Yan Yutong Yang Jianhua Huang Minfeng Wu Xiuli Wang Hongwei Wang Lei Shi Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT Translational Biophotonics 5‐aminolevulinic acid ALA‐PDT KA‐like SCC keratoacanthoma |
| title | Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT |
| title_full | Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT |
| title_fullStr | Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT |
| title_full_unstemmed | Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT |
| title_short | Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT |
| title_sort | keratoacanthoma like squamous cell carcinoma successfully treated by the surgery combined with ala pdt |
| topic | 5‐aminolevulinic acid ALA‐PDT KA‐like SCC keratoacanthoma |
| url | https://doi.org/10.1002/tbio.202200005 |
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