FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS
We have analysed the results of the study of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’lungs in experimental allergic alveolitis in the dynamics of EAA development under the cond...
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| Format: | Article |
| Language: | English |
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Shevchenko Scientific Society
2019-12-01
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| Series: | Праці Наукового товариства імені Шевченка. Медичні науки |
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| Online Access: | https://mspsss.org.ua/index.php/journal/article/view/216 |
| _version_ | 1818340705354907648 |
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| author | Marta Kovalska |
| author_facet | Marta Kovalska |
| author_sort | Marta Kovalska |
| collection | DOAJ |
| description | We have analysed the results of the study of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’lungs in experimental allergic alveolitis in the dynamics of EAA development under the conditions of immobilization stress. The study included 62 female guinea pigs weighing 180-220 g, divided into 4 groups: 1 – intact guinea pigs (n=20); 2 – guinea pigs (n=14) with EAA under conditions of IS (1st day); 3 – guinea pigs (n=14) with EAA under conditions of IS (2nd day); 4 – guinea pigs (n=14) with EAA under conditions of IS (34th day). The results of the experimental study showed that a signifi cant increase in conjugated diene level in animal lungs was observed at all stages of EAA development under conditions of immobilization stress as compared to a control group, indicating the activation of this marker. The same changes occurred with MDA content, indicating excessive accumulation of this lipid peroxidation product in lung tissue. Intensive synthesis of free radical compounds caused activation of some components of the enzymatic system of antioxidant defence. In particular, a moderate decrease in superoxide dismutase activity in lung tissue is observed in response to an increased level of LOPs at early stages of EAA and immobilization stress development as compared to these indices in intact animals. The same situation is observed with catalase and ceruloplasmin activity in the lungs of guinea pigs with modelled AA and IS. |
| first_indexed | 2024-12-13T15:47:09Z |
| format | Article |
| id | doaj.art-78a76e0bd1024c35b38118d7e6c8eb36 |
| institution | Directory Open Access Journal |
| issn | 2708-8634 2708-8642 |
| language | English |
| last_indexed | 2024-12-13T15:47:09Z |
| publishDate | 2019-12-01 |
| publisher | Shevchenko Scientific Society |
| record_format | Article |
| series | Праці Наукового товариства імені Шевченка. Медичні науки |
| spelling | doaj.art-78a76e0bd1024c35b38118d7e6c8eb362022-12-21T23:39:39ZengShevchenko Scientific SocietyПраці Наукового товариства імені Шевченка. Медичні науки2708-86342708-86422019-12-0157210.25040/ntsh2019.02.11216FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESSMarta Kovalska0Danylo Halytsky Lviv national medical university Department of pathological physiology, PhD, assistant of Professor Lviv, UkraineWe have analysed the results of the study of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’lungs in experimental allergic alveolitis in the dynamics of EAA development under the conditions of immobilization stress. The study included 62 female guinea pigs weighing 180-220 g, divided into 4 groups: 1 – intact guinea pigs (n=20); 2 – guinea pigs (n=14) with EAA under conditions of IS (1st day); 3 – guinea pigs (n=14) with EAA under conditions of IS (2nd day); 4 – guinea pigs (n=14) with EAA under conditions of IS (34th day). The results of the experimental study showed that a signifi cant increase in conjugated diene level in animal lungs was observed at all stages of EAA development under conditions of immobilization stress as compared to a control group, indicating the activation of this marker. The same changes occurred with MDA content, indicating excessive accumulation of this lipid peroxidation product in lung tissue. Intensive synthesis of free radical compounds caused activation of some components of the enzymatic system of antioxidant defence. In particular, a moderate decrease in superoxide dismutase activity in lung tissue is observed in response to an increased level of LOPs at early stages of EAA and immobilization stress development as compared to these indices in intact animals. The same situation is observed with catalase and ceruloplasmin activity in the lungs of guinea pigs with modelled AA and IS.https://mspsss.org.ua/index.php/journal/article/view/216experimental allergic alveolitis, immobilization stress, peroxide lipid oxidation, anti- oxidant system |
| spellingShingle | Marta Kovalska FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS Праці Наукового товариства імені Шевченка. Медичні науки experimental allergic alveolitis, immobilization stress, peroxide lipid oxidation, anti- oxidant system |
| title | FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS |
| title_full | FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS |
| title_fullStr | FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS |
| title_full_unstemmed | FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS |
| title_short | FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS |
| title_sort | functional status of prooxidant and antioxidant systems in the lungs under experimental allergic alveolitis and stress |
| topic | experimental allergic alveolitis, immobilization stress, peroxide lipid oxidation, anti- oxidant system |
| url | https://mspsss.org.ua/index.php/journal/article/view/216 |
| work_keys_str_mv | AT martakovalska functionalstatusofprooxidantandantioxidantsystemsinthelungsunderexperimentalallergicalveolitisandstress |