Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats

Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats

Background: Neuroinflammation is a hallmark in intracerebral hemorrhage (ICH) that induces secondary brain injury, leading to neuronal cell death. ER stress-triggered apoptosis and proteostasis disruption caused neuroinflammation to play an important role in various neurological disorders. The conse...

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Bibliographic Details
Main Authors: Hock-Kean Liew, Wei-Fen Hu, Peter Bor-Chian Lin, Po-Kai Wang, Andy Po-Yi Tsai, Cheng-Yoong Pang, Tsung-Ying Chen
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
er stress
grp78
intracerebral hemorrhage
nfκb
oxidative stress
proteasome activity
proteostasis disturbance
protein aggregation
ubiquitination
Online Access:https://www.mdpi.com/2073-4409/8/11/1326

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