Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome
Abstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertility age that FBN3 gene is one...
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Qom Islamic Azad University
2019-10-01
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| Series: | بیولوژی کاربردی |
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| Online Access: | https://sjoapb.qom.iau.ir/article_672411_5940b0e03fb6ffae2b514a82168865d7.pdf |
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| author | Reyhaneh Kalhor naser kalhor Hourieh Kalhor Mojtaba Sohrabi |
| author_facet | Reyhaneh Kalhor naser kalhor Hourieh Kalhor Mojtaba Sohrabi |
| author_sort | Reyhaneh Kalhor |
| collection | DOAJ |
| description | Abstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertility age that FBN3 gene is one of the most important candidate genes, for PCOS. This gene has 20 polymorphisms. This study examines the relationship between rs2303169 polymorphism in FBN3 gene in women with PCOS. Method: This study is a case-control study which is done on 100 women with PCOS and 100 healthy women. In this research, Tetra-ARMS PCR method was used to study the relationship between rs2390169 genotypes in FBN3 gene and the probability of getting PCOS in both patient and control groups. Connecting data from this study are analyzed statistically using SPSS software, chi-squared tests and Independent student t-test. Results: The results of the research showed no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS (P = 0.152). Also, CT and TT genotypes increased the probability of getting PCOS to 1,995 and 1,621 times towards CC genotype respectively. Conclusion: For the first time, this study showed that there is no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS. However, relationship between polymorphisms of other genotypes in FBN3 gene and PCOS needs a wider research in greater populations and different ethnicities in the country. Key words: Polycystic ovary syndrome; Polymorphism; FBN3 gene. |
| first_indexed | 2024-03-12T23:13:33Z |
| format | Article |
| id | doaj.art-78aa9885cd7f4fdc9771c7319fedf414 |
| institution | Directory Open Access Journal |
| issn | 2538-3434 |
| language | fas |
| last_indexed | 2024-03-12T23:13:33Z |
| publishDate | 2019-10-01 |
| publisher | Qom Islamic Azad University |
| record_format | Article |
| series | بیولوژی کاربردی |
| spelling | doaj.art-78aa9885cd7f4fdc9771c7319fedf4142023-07-17T14:57:33ZfasQom Islamic Azad Universityبیولوژی کاربردی2538-34342019-10-01935117672411Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndromeReyhaneh Kalhor0naser kalhor1Hourieh Kalhor2Mojtaba Sohrabi3Department of Biology, Qom branch, Islamic azad University, Qom, Iranجهاددانشگاهی استان قمDepartment and Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran- Department of Biology, Qom branch, Islamic azad University, Qom, Iran.Abstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertility age that FBN3 gene is one of the most important candidate genes, for PCOS. This gene has 20 polymorphisms. This study examines the relationship between rs2303169 polymorphism in FBN3 gene in women with PCOS. Method: This study is a case-control study which is done on 100 women with PCOS and 100 healthy women. In this research, Tetra-ARMS PCR method was used to study the relationship between rs2390169 genotypes in FBN3 gene and the probability of getting PCOS in both patient and control groups. Connecting data from this study are analyzed statistically using SPSS software, chi-squared tests and Independent student t-test. Results: The results of the research showed no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS (P = 0.152). Also, CT and TT genotypes increased the probability of getting PCOS to 1,995 and 1,621 times towards CC genotype respectively. Conclusion: For the first time, this study showed that there is no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS. However, relationship between polymorphisms of other genotypes in FBN3 gene and PCOS needs a wider research in greater populations and different ethnicities in the country. Key words: Polycystic ovary syndrome; Polymorphism; FBN3 gene.https://sjoapb.qom.iau.ir/article_672411_5940b0e03fb6ffae2b514a82168865d7.pdfpolycystic ovary syndromepolymorphismrs2303169fbn3 gene |
| spellingShingle | Reyhaneh Kalhor naser kalhor Hourieh Kalhor Mojtaba Sohrabi Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome بیولوژی کاربردی polycystic ovary syndrome polymorphism rs2303169 fbn3 gene |
| title | Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome |
| title_full | Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome |
| title_fullStr | Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome |
| title_full_unstemmed | Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome |
| title_short | Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome |
| title_sort | survey relationship between rs2303169 polymorphism in fbn3 gene in patients with polycystic ovary syndrome |
| topic | polycystic ovary syndrome polymorphism rs2303169 fbn3 gene |
| url | https://sjoapb.qom.iau.ir/article_672411_5940b0e03fb6ffae2b514a82168865d7.pdf |
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