Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases
Abstract Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases. This...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Clinical & Translational Immunology |
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| Online Access: | https://doi.org/10.1002/cti2.1139 |
| _version_ | 1818480532042809344 |
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| author | Yishan Ye Béatrice Gaugler Mohamad Mohty Florent Malard |
| author_facet | Yishan Ye Béatrice Gaugler Mohamad Mohty Florent Malard |
| author_sort | Yishan Ye |
| collection | DOAJ |
| description | Abstract Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases. This review summarises the latest advances in recent years in several aspects of pDC biology, with special focus on pDC heterogeneity, pDC development via the lymphoid pathway, and newly identified proteins/pathways involved in pDC trafficking, nucleic acid sensing and interferon production. Finally, we also highlight the current understanding of pDC involvement in autoimmunity and alloreactivity, and opportunities for pDC‐targeting therapies in these diseases. These new insights have contributed to answers to several fundamental questions remaining in pDC biology and may pave the way to successful pDC‐targeting therapy in the future. |
| first_indexed | 2024-12-10T11:24:55Z |
| format | Article |
| id | doaj.art-78aca2971e5d40399fd33a03ede87ca4 |
| institution | Directory Open Access Journal |
| issn | 2050-0068 |
| language | English |
| last_indexed | 2024-12-10T11:24:55Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical & Translational Immunology |
| spelling | doaj.art-78aca2971e5d40399fd33a03ede87ca42022-12-22T01:50:46ZengWileyClinical & Translational Immunology2050-00682020-01-0195n/an/a10.1002/cti2.1139Plasmacytoid dendritic cell biology and its role in immune‐mediated diseasesYishan Ye0Béatrice Gaugler1Mohamad Mohty2Florent Malard3INSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Université Paris FranceINSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Université Paris FranceINSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Université Paris FranceINSERM, Centre de Recherche Saint‐Antoine (CRSA) Sorbonne Université Paris FranceAbstract Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases. This review summarises the latest advances in recent years in several aspects of pDC biology, with special focus on pDC heterogeneity, pDC development via the lymphoid pathway, and newly identified proteins/pathways involved in pDC trafficking, nucleic acid sensing and interferon production. Finally, we also highlight the current understanding of pDC involvement in autoimmunity and alloreactivity, and opportunities for pDC‐targeting therapies in these diseases. These new insights have contributed to answers to several fundamental questions remaining in pDC biology and may pave the way to successful pDC‐targeting therapy in the future.https://doi.org/10.1002/cti2.1139alloreactivityautoimmunitycell developmentimmunotherapyplasmacytoid dendritic cells |
| spellingShingle | Yishan Ye Béatrice Gaugler Mohamad Mohty Florent Malard Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases Clinical & Translational Immunology alloreactivity autoimmunity cell development immunotherapy plasmacytoid dendritic cells |
| title | Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases |
| title_full | Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases |
| title_fullStr | Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases |
| title_full_unstemmed | Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases |
| title_short | Plasmacytoid dendritic cell biology and its role in immune‐mediated diseases |
| title_sort | plasmacytoid dendritic cell biology and its role in immune mediated diseases |
| topic | alloreactivity autoimmunity cell development immunotherapy plasmacytoid dendritic cells |
| url | https://doi.org/10.1002/cti2.1139 |
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