β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells.

β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells.

Cancer related deaths are primarily due to tumor metastasis. To facilitate their dissemination to distant sites, cancer cells develop invadopodia, actin-rich protrusions capable of degrading the surrounding extracellular matrix (ECM). We aimed to determine whether β3 integrin participates in invadop...

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Bibliographic Details
Main Authors: Rafael Peláez, Xabier Morales, Elizabeth Salvo, Saray Garasa, Carlos Ortiz de Solórzano, Alfredo Martínez, Ignacio M Larrayoz, Ana Rouzaut
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5540285?pdf=render

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