Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature
Introduction: The etiopathogenesis of pelviureteric junction obstruction (PUJO) has been debated. Recently, the role of interstitial cells of Cajal-like cells (ICC-LC) has been studied and reported to be the cause of this functional obstruction. We studied the histopathology and ICC-LC density at PU...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Indian Association of Pediatric Surgeons |
| Subjects: | |
| Online Access: | http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=4;spage=395;epage=401;aulast=Nandan |
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| author | Ruchira Nandan Vishesh Jain Sandeep Agarwala Prasenjit Das Prabudh Goel Mani Kalaivani Devendra Kumar Yadav |
| author_facet | Ruchira Nandan Vishesh Jain Sandeep Agarwala Prasenjit Das Prabudh Goel Mani Kalaivani Devendra Kumar Yadav |
| author_sort | Ruchira Nandan |
| collection | DOAJ |
| description | Introduction: The etiopathogenesis of pelviureteric junction obstruction (PUJO) has been debated. Recently, the role of interstitial cells of Cajal-like cells (ICC-LC) has been studied and reported to be the cause of this functional obstruction. We studied the histopathology and ICC-LC density at PUJ and compared it with that of PUJ of the control group and distal ureteric margin of the study group.
Methods: A prospective study was conducted which included PUJO patients in the study group and the renal tumor patients in the control group. Histopathological examination (muscle hypertrophy and fibrosis) and immunohistochemistry (ICC-LC density) were done. The muscle hypertrophy, fibrosis, and ICC-LC density at the PUJ in both the groups were compared. A similar comparison was performed between the findings at the PUJ and the distal margin in the study group.
Results: The study and control groups included 37 PUJO patients and 13 Wilms tumor patients. The ICC-LC density at PUJ in the study group was significantly lower than that in the control group (P < 0.001) and that at the distal resected margin of the study group (P < 0.001). Significantly increased muscle hypertrophy (P < 0.001) and fibrosis (P = 0.002) were seen at PUJ in the study group compared to the control group. No significant association was noted between the ICC-LC density and muscle hypertrophy at PUJ and the distal resected margin in the study group.
Conclusion: A significant decrease in the density of ICC-LC and increased fibrosis and muscle hypertrophy at PUJ in children with PUJO play a role in the etiopathogenesis of the disease. |
| first_indexed | 2024-04-13T09:44:51Z |
| format | Article |
| id | doaj.art-78aebc16b6d5446a8353b108d4480313 |
| institution | Directory Open Access Journal |
| issn | 0971-9261 1998-3891 |
| language | English |
| last_indexed | 2024-04-13T09:44:51Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Association of Pediatric Surgeons |
| spelling | doaj.art-78aebc16b6d5446a8353b108d44803132022-12-22T02:51:47ZengWolters Kluwer Medknow PublicationsJournal of Indian Association of Pediatric Surgeons0971-92611998-38912022-01-0127439540110.4103/jiaps.jiaps_103_21Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literatureRuchira NandanVishesh JainSandeep AgarwalaPrasenjit DasPrabudh GoelMani KalaivaniDevendra Kumar YadavIntroduction: The etiopathogenesis of pelviureteric junction obstruction (PUJO) has been debated. Recently, the role of interstitial cells of Cajal-like cells (ICC-LC) has been studied and reported to be the cause of this functional obstruction. We studied the histopathology and ICC-LC density at PUJ and compared it with that of PUJ of the control group and distal ureteric margin of the study group. Methods: A prospective study was conducted which included PUJO patients in the study group and the renal tumor patients in the control group. Histopathological examination (muscle hypertrophy and fibrosis) and immunohistochemistry (ICC-LC density) were done. The muscle hypertrophy, fibrosis, and ICC-LC density at the PUJ in both the groups were compared. A similar comparison was performed between the findings at the PUJ and the distal margin in the study group. Results: The study and control groups included 37 PUJO patients and 13 Wilms tumor patients. The ICC-LC density at PUJ in the study group was significantly lower than that in the control group (P < 0.001) and that at the distal resected margin of the study group (P < 0.001). Significantly increased muscle hypertrophy (P < 0.001) and fibrosis (P = 0.002) were seen at PUJ in the study group compared to the control group. No significant association was noted between the ICC-LC density and muscle hypertrophy at PUJ and the distal resected margin in the study group. Conclusion: A significant decrease in the density of ICC-LC and increased fibrosis and muscle hypertrophy at PUJ in children with PUJO play a role in the etiopathogenesis of the disease.http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=4;spage=395;epage=401;aulast=Nandanhydronephrosisinterstitial cells of cajal-like cellsinterstitial cells of cajalpelviureteric junction obstruction |
| spellingShingle | Ruchira Nandan Vishesh Jain Sandeep Agarwala Prasenjit Das Prabudh Goel Mani Kalaivani Devendra Kumar Yadav Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature Journal of Indian Association of Pediatric Surgeons hydronephrosis interstitial cells of cajal-like cells interstitial cells of cajal pelviureteric junction obstruction |
| title | Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature |
| title_full | Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature |
| title_fullStr | Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature |
| title_full_unstemmed | Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature |
| title_short | Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature |
| title_sort | evaluation of interstitial cells of cajal like cells at the pelviureteric junction in children with pelviureteric junction obstruction a prospective study and review of literature |
| topic | hydronephrosis interstitial cells of cajal-like cells interstitial cells of cajal pelviureteric junction obstruction |
| url | http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=4;spage=395;epage=401;aulast=Nandan |
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