In Vitro Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein

In Vitro Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein

Inhibition of cytochrome P450 (CYP) and P-glycoprotein (P-gp) are regarded as the most frequent and clinically important pharmacokinetic causes among the various possible factors for drug-drug interactions. Scutellarin is a flavonoid which is widely used for the treatment of cardiovascular diseases....

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Bibliographic Details
Main Authors: Yong-Long Han, Dan Li, Quan-Jun Yang, Zhi-Yong Zhou, Li-Ya Liu, Bin Li, Jin Lu, Cheng Guo
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
scutellarin
cytochrome P450
P-glycoprotein
herb-drug interactions
Online Access:http://www.mdpi.com/1420-3049/19/5/5748

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