MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome
Abstract Background The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis an...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-017-0971-6 |
| _version_ | 1811330981299224576 |
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| author | Sara Mariotto Salvatore Monaco Patrick Peschl Ilaria Coledan Romualdo Mazzi Romana Höftberger Markus Reindl Sergio Ferrari |
| author_facet | Sara Mariotto Salvatore Monaco Patrick Peschl Ilaria Coledan Romualdo Mazzi Romana Höftberger Markus Reindl Sergio Ferrari |
| author_sort | Sara Mariotto |
| collection | DOAJ |
| description | Abstract Background The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal fluid MOG-Abs and a clinical picture suggestive for acute encephalitis. Case presentation A 31-year-old Indian man presented with altered mental status, slight fever, and ataxia. Brain magnetic resonance imaging noted a widespread involvement of the white matter associated with slight cortical and subcortical damage in absence of contrast enhancement. An extensive infectious screening resulted negative while autoimmune analysis revealed the presence of MOG-Abs, detected with live cell-based assay. After treatment with intravenous immunoglobulins a marked and prompt clinical and radiological improvement was observed. Conclusions To date, several areas of uncertainty still remain regarding clinical features and prognosis of subjects with MOG-Abs. The description of atypical cases is crucial, since recognition of this condition leads to prompt treatment and better prognosis, as in the case here reported. |
| first_indexed | 2024-04-13T16:11:58Z |
| format | Article |
| id | doaj.art-78b073234f2d45b590fb4a9338c5c61c |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-13T16:11:58Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-78b073234f2d45b590fb4a9338c5c61c2022-12-22T02:40:13ZengBMCBMC Neurology1471-23772017-10-011711610.1186/s12883-017-0971-6MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndromeSara Mariotto0Salvatore Monaco1Patrick Peschl2Ilaria Coledan3Romualdo Mazzi4Romana Höftberger5Markus Reindl6Sergio Ferrari7Department of Neuroscience, Biomedicine and Movement Sciences, Section of Neurology, University of VeronaDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Neurology, University of VeronaClinical Department of Neurology, Medical University of InnsbruckDepartment of Diagnostics and Public Health, Section of Infectious Diseases, University of VeronaDepartment of Diagnostics and Public Health, Section of Infectious Diseases, University of VeronaInstitute of Neurology, Medical University of ViennaClinical Department of Neurology, Medical University of InnsbruckDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Neurology, University of VeronaAbstract Background The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal fluid MOG-Abs and a clinical picture suggestive for acute encephalitis. Case presentation A 31-year-old Indian man presented with altered mental status, slight fever, and ataxia. Brain magnetic resonance imaging noted a widespread involvement of the white matter associated with slight cortical and subcortical damage in absence of contrast enhancement. An extensive infectious screening resulted negative while autoimmune analysis revealed the presence of MOG-Abs, detected with live cell-based assay. After treatment with intravenous immunoglobulins a marked and prompt clinical and radiological improvement was observed. Conclusions To date, several areas of uncertainty still remain regarding clinical features and prognosis of subjects with MOG-Abs. The description of atypical cases is crucial, since recognition of this condition leads to prompt treatment and better prognosis, as in the case here reported.http://link.springer.com/article/10.1186/s12883-017-0971-6Autoimmune diseasesEncephalitisAnti-myelin oligodendrocyte glycoprotein antibodies (MOG-abs) |
| spellingShingle | Sara Mariotto Salvatore Monaco Patrick Peschl Ilaria Coledan Romualdo Mazzi Romana Höftberger Markus Reindl Sergio Ferrari MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome BMC Neurology Autoimmune diseases Encephalitis Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-abs) |
| title | MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome |
| title_full | MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome |
| title_fullStr | MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome |
| title_full_unstemmed | MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome |
| title_short | MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome |
| title_sort | mog antibody seropositivity in a patient with encephalitis beyond the classical syndrome |
| topic | Autoimmune diseases Encephalitis Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-abs) |
| url | http://link.springer.com/article/10.1186/s12883-017-0971-6 |
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