Dopaminergic Modulation of Prefrontal Cortex Inhibition
The prefrontal cortex is the highest stage of integration in the mammalian brain. Its functions vary greatly, from working memory to decision-making, and are primarily related to higher cognitive functions. This explains the considerable effort devoted to investigating this area, revealing the compl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/5/1276 |
| _version_ | 1797600930402664448 |
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| author | Danila Di Domenico Lisa Mapelli |
| author_facet | Danila Di Domenico Lisa Mapelli |
| author_sort | Danila Di Domenico |
| collection | DOAJ |
| description | The prefrontal cortex is the highest stage of integration in the mammalian brain. Its functions vary greatly, from working memory to decision-making, and are primarily related to higher cognitive functions. This explains the considerable effort devoted to investigating this area, revealing the complex molecular, cellular, and network organization, and the essential role of various regulatory controls. In particular, the dopaminergic modulation and the impact of local interneurons activity are critical for prefrontal cortex functioning, controlling the excitatory/inhibitory balance and the overall network processing. Though often studied separately, the dopaminergic and GABAergic systems are deeply intertwined in influencing prefrontal network processing. This mini review will focus on the dopaminergic modulation of GABAergic inhibition, which plays a significant role in shaping prefrontal cortex activity. |
| first_indexed | 2024-03-11T03:55:45Z |
| format | Article |
| id | doaj.art-78b0b6631fdd4d01ad293ee02ba56315 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:55:45Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-78b0b6631fdd4d01ad293ee02ba563152023-11-18T00:34:36ZengMDPI AGBiomedicines2227-90592023-04-01115127610.3390/biomedicines11051276Dopaminergic Modulation of Prefrontal Cortex InhibitionDanila Di Domenico0Lisa Mapelli1Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyThe prefrontal cortex is the highest stage of integration in the mammalian brain. Its functions vary greatly, from working memory to decision-making, and are primarily related to higher cognitive functions. This explains the considerable effort devoted to investigating this area, revealing the complex molecular, cellular, and network organization, and the essential role of various regulatory controls. In particular, the dopaminergic modulation and the impact of local interneurons activity are critical for prefrontal cortex functioning, controlling the excitatory/inhibitory balance and the overall network processing. Though often studied separately, the dopaminergic and GABAergic systems are deeply intertwined in influencing prefrontal network processing. This mini review will focus on the dopaminergic modulation of GABAergic inhibition, which plays a significant role in shaping prefrontal cortex activity.https://www.mdpi.com/2227-9059/11/5/1276prefrontal cortexdopaminergic systemGABAergic system |
| spellingShingle | Danila Di Domenico Lisa Mapelli Dopaminergic Modulation of Prefrontal Cortex Inhibition Biomedicines prefrontal cortex dopaminergic system GABAergic system |
| title | Dopaminergic Modulation of Prefrontal Cortex Inhibition |
| title_full | Dopaminergic Modulation of Prefrontal Cortex Inhibition |
| title_fullStr | Dopaminergic Modulation of Prefrontal Cortex Inhibition |
| title_full_unstemmed | Dopaminergic Modulation of Prefrontal Cortex Inhibition |
| title_short | Dopaminergic Modulation of Prefrontal Cortex Inhibition |
| title_sort | dopaminergic modulation of prefrontal cortex inhibition |
| topic | prefrontal cortex dopaminergic system GABAergic system |
| url | https://www.mdpi.com/2227-9059/11/5/1276 |
| work_keys_str_mv | AT daniladidomenico dopaminergicmodulationofprefrontalcortexinhibition AT lisamapelli dopaminergicmodulationofprefrontalcortexinhibition |