Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 infection and post-COVID sequelae remain to be understood. Her...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/73522 |
| _version_ | 1811199407189655552 |
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| author | Zaigham Abbas Rizvi Rajdeep Dalal Srikanth Sadhu Akshay Binayke Jyotsna Dandotiya Yashwant Kumar Tripti Shrivastava Sonu Kumar Gupta Suruchi Aggarwal Manas Ranjan Tripathy Deepak Kumar Rathore Amit Kumar Yadav Guruprasad R Medigeshi Amit Kumar Pandey Sweety Samal Shailendra Asthana Amit Awasthi |
| author_facet | Zaigham Abbas Rizvi Rajdeep Dalal Srikanth Sadhu Akshay Binayke Jyotsna Dandotiya Yashwant Kumar Tripti Shrivastava Sonu Kumar Gupta Suruchi Aggarwal Manas Ranjan Tripathy Deepak Kumar Rathore Amit Kumar Yadav Guruprasad R Medigeshi Amit Kumar Pandey Sweety Samal Shailendra Asthana Amit Awasthi |
| author_sort | Zaigham Abbas Rizvi |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 infection and post-COVID sequelae remain to be understood. Here, we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVCs) characterized by ventricular wall thickening associated with increased ventricular mass/body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac troponin I, cholesterol, low-density lipoprotein, and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC, which could be extended to therapeutic interventions. |
| first_indexed | 2024-04-12T01:48:25Z |
| format | Article |
| id | doaj.art-78b2b9d894bf4efaab700a2327c7617c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:48:25Z |
| publishDate | 2022-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-78b2b9d894bf4efaab700a2327c7617c2022-12-22T03:53:01ZengeLife Sciences Publications LtdeLife2050-084X2022-01-011110.7554/eLife.73522Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infectionZaigham Abbas Rizvi0https://orcid.org/0000-0001-7850-5672Rajdeep Dalal1Srikanth Sadhu2Akshay Binayke3https://orcid.org/0000-0002-9808-9036Jyotsna Dandotiya4Yashwant Kumar5Tripti Shrivastava6Sonu Kumar Gupta7Suruchi Aggarwal8Manas Ranjan Tripathy9Deepak Kumar Rathore10Amit Kumar Yadav11https://orcid.org/0000-0002-9445-8156Guruprasad R Medigeshi12Amit Kumar Pandey13Sweety Samal14Shailendra Asthana15Amit Awasthi16https://orcid.org/0000-0002-2563-1971Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India; Immunology Core, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaImmuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaImmuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaImmuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaImmuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaNon-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaInfection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaNon-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaNon-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaImmuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaInfection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaNon-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaInfection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaInfection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaInfection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaNon-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaImmuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India; Immunology Core, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, IndiaSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 infection and post-COVID sequelae remain to be understood. Here, we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVCs) characterized by ventricular wall thickening associated with increased ventricular mass/body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac troponin I, cholesterol, low-density lipoprotein, and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC, which could be extended to therapeutic interventions.https://elifesciences.org/articles/73522hamsterSARS-CoV2cardiovascular |
| spellingShingle | Zaigham Abbas Rizvi Rajdeep Dalal Srikanth Sadhu Akshay Binayke Jyotsna Dandotiya Yashwant Kumar Tripti Shrivastava Sonu Kumar Gupta Suruchi Aggarwal Manas Ranjan Tripathy Deepak Kumar Rathore Amit Kumar Yadav Guruprasad R Medigeshi Amit Kumar Pandey Sweety Samal Shailendra Asthana Amit Awasthi Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection eLife hamster SARS-CoV2 cardiovascular |
| title | Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection |
| title_full | Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection |
| title_fullStr | Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection |
| title_full_unstemmed | Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection |
| title_short | Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection |
| title_sort | golden syrian hamster as a model to study cardiovascular complications associated with sars cov 2 infection |
| topic | hamster SARS-CoV2 cardiovascular |
| url | https://elifesciences.org/articles/73522 |
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