Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal s...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06323-w |
| _version_ | 1819122500722753536 |
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| author | Jonathan Dorival Fanny Risser Christophe Jacob Sabrina Collin Gerald Dräger Cédric Paris Benjamin Chagot Andreas Kirschning Arnaud Gruez Kira J. Weissman |
| author_facet | Jonathan Dorival Fanny Risser Christophe Jacob Sabrina Collin Gerald Dräger Cédric Paris Benjamin Chagot Andreas Kirschning Arnaud Gruez Kira J. Weissman |
| author_sort | Jonathan Dorival |
| collection | DOAJ |
| description | The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal structures, which explains the unusual dual activity of LkcE. |
| first_indexed | 2024-12-22T06:53:27Z |
| format | Article |
| id | doaj.art-78b38c0a3e20488982c5b94105e162f4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T06:53:27Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-78b38c0a3e20488982c5b94105e162f42022-12-21T18:35:03ZengNature PortfolioNature Communications2041-17232018-09-019111210.1038/s41467-018-06323-wInsights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesisJonathan Dorival0Fanny Risser1Christophe Jacob2Sabrina Collin3Gerald Dräger4Cédric Paris5Benjamin Chagot6Andreas Kirschning7Arnaud Gruez8Kira J. Weissman9UMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineUMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineUMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineUMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineInstitut für Organische Chemie, Leibniz Universität HannoverLaboratoire d’Ingénierie des Biomolécules, Ecole Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), Université de LorraineUMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineInstitut für Organische Chemie, Leibniz Universität HannoverUMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineUMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de LorraineThe monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal structures, which explains the unusual dual activity of LkcE.https://doi.org/10.1038/s41467-018-06323-w |
| spellingShingle | Jonathan Dorival Fanny Risser Christophe Jacob Sabrina Collin Gerald Dräger Cédric Paris Benjamin Chagot Andreas Kirschning Arnaud Gruez Kira J. Weissman Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis Nature Communications |
| title | Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis |
| title_full | Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis |
| title_fullStr | Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis |
| title_full_unstemmed | Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis |
| title_short | Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis |
| title_sort | insights into a dual function amide oxidase macrocyclase from lankacidin biosynthesis |
| url | https://doi.org/10.1038/s41467-018-06323-w |
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