Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study
Objective: This study aimed to explore the long-term outcome of unilateral moyamoya disease and predict the clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease. Methods: We retrospectively recruited unilateral moyamoya disease patients with available...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402402139X |
| _version_ | 1797267743009931264 |
|---|---|
| author | Xiao-Peng Wang Zheng-Xing Zou Xiang-Yang Bao Qian-Nan Wang Bin Ren Dan Yu Qian Zhang Jia-Qi Liu Fang-Bin Hao Gan Gao Qing-Bao Guo He-Guan Fu Jing-Jie Li Min-Jie Wang Si-Meng Liu Lian Duan |
| author_facet | Xiao-Peng Wang Zheng-Xing Zou Xiang-Yang Bao Qian-Nan Wang Bin Ren Dan Yu Qian Zhang Jia-Qi Liu Fang-Bin Hao Gan Gao Qing-Bao Guo He-Guan Fu Jing-Jie Li Min-Jie Wang Si-Meng Liu Lian Duan |
| author_sort | Xiao-Peng Wang |
| collection | DOAJ |
| description | Objective: This study aimed to explore the long-term outcome of unilateral moyamoya disease and predict the clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease. Methods: We retrospectively recruited unilateral moyamoya disease patients with available genetic data who underwent encephaloduroarteriosynangiosis (EDAS) surgery at our institution from January 2009 to November 2017. Long-term follow-up data, including clinical outcomes, angiographic features, and genetic information, were analyzed. Results: A total of 83 unilateral moyamoya disease patients with available genetic data were enrolled in our study. The mean duration of clinical follow-up was 7.9 ± 2.0 years. Among all patients, 19 patients demonstrated contralateral progression to bilateral disease. Heterozygous Ring Finger Protein 213 p.R4810K mutations occurred significantly more frequently in unilateral moyamoya disease patients with contralateral progression. Furthermore, patients with contralateral progression typically demonstrated an earlier age of onset than those with non-progressing unilateral moyamoya disease. In the contralateral progression group, posterior circulation involvement was observed in 11 (11/19, 57.9%) patients compared to 12 (12/64, 18.8%) in the non-contralateral progression group (P = 0.001). The time to peak of cerebral perfusion and neurological status showed significant postoperative improvement. Conclusion: Long-term follow-up revealed that the EDAS procedure might provide benefits for unilateral moyamoya disease patients. Ring Finger Protein 213 p.R4810K mutations, younger age, and posterior circulation involvement might predict the contralateral progression of unilateral moyamoya disease. |
| first_indexed | 2024-04-25T01:21:26Z |
| format | Article |
| id | doaj.art-78b41b6a205645f7915040b8651fbbd2 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:21:26Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-78b41b6a205645f7915040b8651fbbd22024-03-09T09:27:14ZengElsevierHeliyon2405-84402024-02-01104e26108Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional StudyXiao-Peng Wang0Zheng-Xing Zou1Xiang-Yang Bao2Qian-Nan Wang3Bin Ren4Dan Yu5Qian Zhang6Jia-Qi Liu7Fang-Bin Hao8Gan Gao9Qing-Bao Guo10He-Guan Fu11Jing-Jie Li12Min-Jie Wang13Si-Meng Liu14Lian Duan15Medical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaDepartment of Neurosurgery, the Eighth Medical Center of Chinese PLA General Hospital, Beijing, 100000, ChinaDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaDepartment of Neurosurgery, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, ChinaDepartment of Neurosurgery, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, ChinaDepartment of Neurology, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaDepartment of Neurosurgery, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaMedical School of Chinese PLA, Beijing, 100039, China; Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, 100039, China; Corresponding author. Medical School of Chinese PLA, Beijing, 100039, China.Objective: This study aimed to explore the long-term outcome of unilateral moyamoya disease and predict the clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease. Methods: We retrospectively recruited unilateral moyamoya disease patients with available genetic data who underwent encephaloduroarteriosynangiosis (EDAS) surgery at our institution from January 2009 to November 2017. Long-term follow-up data, including clinical outcomes, angiographic features, and genetic information, were analyzed. Results: A total of 83 unilateral moyamoya disease patients with available genetic data were enrolled in our study. The mean duration of clinical follow-up was 7.9 ± 2.0 years. Among all patients, 19 patients demonstrated contralateral progression to bilateral disease. Heterozygous Ring Finger Protein 213 p.R4810K mutations occurred significantly more frequently in unilateral moyamoya disease patients with contralateral progression. Furthermore, patients with contralateral progression typically demonstrated an earlier age of onset than those with non-progressing unilateral moyamoya disease. In the contralateral progression group, posterior circulation involvement was observed in 11 (11/19, 57.9%) patients compared to 12 (12/64, 18.8%) in the non-contralateral progression group (P = 0.001). The time to peak of cerebral perfusion and neurological status showed significant postoperative improvement. Conclusion: Long-term follow-up revealed that the EDAS procedure might provide benefits for unilateral moyamoya disease patients. Ring Finger Protein 213 p.R4810K mutations, younger age, and posterior circulation involvement might predict the contralateral progression of unilateral moyamoya disease.http://www.sciencedirect.com/science/article/pii/S240584402402139X |
| spellingShingle | Xiao-Peng Wang Zheng-Xing Zou Xiang-Yang Bao Qian-Nan Wang Bin Ren Dan Yu Qian Zhang Jia-Qi Liu Fang-Bin Hao Gan Gao Qing-Bao Guo He-Guan Fu Jing-Jie Li Min-Jie Wang Si-Meng Liu Lian Duan Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study Heliyon |
| title | Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study |
| title_full | Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study |
| title_fullStr | Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study |
| title_full_unstemmed | Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study |
| title_short | Clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease: Longitudinal and Cross-Sectional Study |
| title_sort | clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease longitudinal and cross sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S240584402402139X |
| work_keys_str_mv | AT xiaopengwang clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT zhengxingzou clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT xiangyangbao clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT qiannanwang clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT binren clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT danyu clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT qianzhang clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT jiaqiliu clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT fangbinhao clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT gangao clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT qingbaoguo clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT heguanfu clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT jingjieli clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT minjiewang clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT simengliu clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy AT lianduan clinicalandgeneticfactorsassociatedwithcontralateralprogressioninunilateralmoyamoyadiseaselongitudinalandcrosssectionalstudy |