Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques
<div> <b>Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques</b> </div> <div> <b><br> </b> </div> O.A. Gromova<sup>1</sup>, I.Yu. Torshin<sup>1</su...
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| Format: | Article |
| Language: | Russian |
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LCC «Medicine-Inform»
2018-09-01
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| Series: | РМЖ. Мать и дитя |
| Online Access: | http://wchjournal.com/upload/iblock/479/47972a56043980f9b3024c5b3f3b723d.pdf |
| Summary: | <div>
<b>Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques</b>
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O.A. Gromova<sup>1</sup>, I.Yu. Torshin<sup>1</sup>, A.G. Kalacheva<sup>2</sup>, N.K. Tetruashvili<sup>3</sup><br>
<sup>1</sup> IPI RAN, Moscow, Russian Federation<br>
<sup>2</sup> FSBEI HE IvSMA MOН Russia, Ivanovo, Russian Federation<br>
<sup>3</sup> V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Moscow, Russian Federation<br>
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Myo-inositol is an essential component of human metabolome: for at least 120 inositol phosphate-dependent proteins, there is reliable information about their specific participation in maintaining of reproductive system functioning, embryo development, fetal brain neuroprotection, and insulin signaling cascade activity. Accordingly, metabolic disorders of the myo-inositol lead to insulin resistance, cell resistance to gonadotropin-releasing hormone, follicle-stimulating and luteinizing hormones, ovulation disorders, inhibition of oocyte maturation. An involvement of myo-inositol phospho derivatives in intracellular signal transmission from reproductive hormones receptors determines effectiveness of myo-inositol drug action on normalizing processes of reproductive hormone levels and ovulation. Use of the myo-inositol is effective in the treatment of polycystic ovarian syndrome and reduces a risk of folate-resistant developmental malformations. It is also promising to use the myo-inositol for in vitro fertilization (IVF) preparation. Meta-analyzes of randomized trials have confirmed myo-inositol efficacy (2–4 g/day, at least 3 months) in increasing of frequency of pregnancy in infertile women who undergo induction of ovulation or in vitro embryo transplantation. The data cited above indicate importance of establishing availability of myo-inositol to patients undergoing the IVF, as myo-inositol level in the blood is an important biomarker of women’s somatic and reproductive health. An effective method of correcting reproductive disorders in women is the use of myo-inositol (especially in combination with folates).<br>
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<b>Key words:</b> myo-inositol, folates, menstrual cycle, pregravid preparation, oocyte quality, Myofert.<br>
<b>For citation:</b> Gromova O.A., Torshin I.Yu., Kalacheva A.G., Tetruashvili N.K. Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques. Russian journal of Woman and Child Health. 2018;1(1):–95.<br> |
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| ISSN: | 2618-8430 2686-7184 |