Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD

Highly contagious respiratory illnesses like influenza and COVID-19 pose serious risks to public health. A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. Here, we generated a chimeric receptor binding domain of the spike protein (S-RBD) and hemagglutinin (HA)-st...

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Bibliographic Details
Main Authors: Yulei Li, Peipei Liu, Tianjiao Hao, Sheng Liu, Xi Wang, Yufeng Xie, Ke Xu, Wenwen Lei, Cheng Zhang, Pu Han, Ying Li, Xiyue Jin, Yu Huan, Yafei Lu, Rong Zhang, Xiaoyan Li, Xin Zhao, Kun Xu, Pu Liao, Xuancheng Lu, Yuhai Bi, Hao Song, Guizhen Wu, Baoli Zhu, George F. Gao
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Universal vaccine
SARS-CoV-2
Omicron
influenza
subunit vaccine
chimeric antigen
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2231573

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