Mottle: Accurate pairwise substitution distance at high divergence through the exploitation of short-read mappers and gradient descent.
Current tools for estimating the substitution distance between two related sequences struggle to remain accurate at a high divergence. Difficulties at distant homologies, such as false seeding and over-alignment, create a high barrier for the development of a stable estimator. This is especially tru...
Main Authors: | Alisa Prusokiene, Neil Boonham, Adrian Fox, Thomas P Howard |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2024-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0298834 |
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