Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior
Proper nutrition and supplementation during pregnancy and breastfeeding are crucial for the development of offspring. Kynurenine (KYN) is the central metabolite of the kynurenine pathway and a direct precursor of other metabolites that possess immunoprotective or neuroactive properties, with the ult...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/18/2224 |
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| author | Marta Marszalek-Grabska Kinga Gawel Nataliia Kosheva Tomasz Kocki Waldemar A. Turski |
| author_facet | Marta Marszalek-Grabska Kinga Gawel Nataliia Kosheva Tomasz Kocki Waldemar A. Turski |
| author_sort | Marta Marszalek-Grabska |
| collection | DOAJ |
| description | Proper nutrition and supplementation during pregnancy and breastfeeding are crucial for the development of offspring. Kynurenine (KYN) is the central metabolite of the kynurenine pathway and a direct precursor of other metabolites that possess immunoprotective or neuroactive properties, with the ultimate effect on fetal neurodevelopment. To date, no studies have evaluated the effects of KYN on early embryonic development. Thus, the aim of our study was to determine the effect of incubation of larvae with KYN in different developmental periods on the behavior of 5-day-old zebrafish. Additionally, the effects exerted by KYN administered on embryonic days 1–7 (ED 1–7) on the behavior of adult offspring of rats were elucidated. Our study revealed that the incubation with KYN induced changes in zebrafish behavior, especially when zebrafish embryos or larvae were incubated with KYN from 1 to 72 h post-fertilization (hpf) and from 49 to 72 hpf. KYN administered early during pregnancy induced subtle differences in the neurobehavioral development of adult offspring. Further research is required to understand the mechanism of these changes. The larval zebrafish model can be useful for studying disturbances in early brain development processes and their late behavioral consequences. The zebrafish-medium system may be applicable in monitoring drug metabolism in zebrafish. |
| first_indexed | 2024-03-10T22:56:19Z |
| format | Article |
| id | doaj.art-78b74704d3cf4e8fad1cdcda52975e04 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:56:19Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj.art-78b74704d3cf4e8fad1cdcda52975e042023-11-19T09:59:03ZengMDPI AGCells2073-44092023-09-011218222410.3390/cells12182224Developmental Exposure to Kynurenine Affects Zebrafish and Rat BehaviorMarta Marszalek-Grabska0Kinga Gawel1Nataliia Kosheva2Tomasz Kocki3Waldemar A. Turski4Department of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, PolandProper nutrition and supplementation during pregnancy and breastfeeding are crucial for the development of offspring. Kynurenine (KYN) is the central metabolite of the kynurenine pathway and a direct precursor of other metabolites that possess immunoprotective or neuroactive properties, with the ultimate effect on fetal neurodevelopment. To date, no studies have evaluated the effects of KYN on early embryonic development. Thus, the aim of our study was to determine the effect of incubation of larvae with KYN in different developmental periods on the behavior of 5-day-old zebrafish. Additionally, the effects exerted by KYN administered on embryonic days 1–7 (ED 1–7) on the behavior of adult offspring of rats were elucidated. Our study revealed that the incubation with KYN induced changes in zebrafish behavior, especially when zebrafish embryos or larvae were incubated with KYN from 1 to 72 h post-fertilization (hpf) and from 49 to 72 hpf. KYN administered early during pregnancy induced subtle differences in the neurobehavioral development of adult offspring. Further research is required to understand the mechanism of these changes. The larval zebrafish model can be useful for studying disturbances in early brain development processes and their late behavioral consequences. The zebrafish-medium system may be applicable in monitoring drug metabolism in zebrafish.https://www.mdpi.com/2073-4409/12/18/2224kynureninedevelopmentbehaviorzebrafishrat |
| spellingShingle | Marta Marszalek-Grabska Kinga Gawel Nataliia Kosheva Tomasz Kocki Waldemar A. Turski Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior Cells kynurenine development behavior zebrafish rat |
| title | Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior |
| title_full | Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior |
| title_fullStr | Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior |
| title_full_unstemmed | Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior |
| title_short | Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior |
| title_sort | developmental exposure to kynurenine affects zebrafish and rat behavior |
| topic | kynurenine development behavior zebrafish rat |
| url | https://www.mdpi.com/2073-4409/12/18/2224 |
| work_keys_str_mv | AT martamarszalekgrabska developmentalexposuretokynurenineaffectszebrafishandratbehavior AT kingagawel developmentalexposuretokynurenineaffectszebrafishandratbehavior AT nataliiakosheva developmentalexposuretokynurenineaffectszebrafishandratbehavior AT tomaszkocki developmentalexposuretokynurenineaffectszebrafishandratbehavior AT waldemaraturski developmentalexposuretokynurenineaffectszebrafishandratbehavior |