Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers
Evidence demonstrated that bones, liver, and lungs are the most common metastasis sites in some human malignancies, especially in prostate and breast cancers. Bone is the third most frequent target for spreading tumor cells among these organs and tissues. Patients with bone-metastatic cancers face a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1260491/full |
| _version_ | 1797362472704802816 |
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| author | Huanrong Lan Bo Wu Ketao Jin Yefeng Chen |
| author_facet | Huanrong Lan Bo Wu Ketao Jin Yefeng Chen |
| author_sort | Huanrong Lan |
| collection | DOAJ |
| description | Evidence demonstrated that bones, liver, and lungs are the most common metastasis sites in some human malignancies, especially in prostate and breast cancers. Bone is the third most frequent target for spreading tumor cells among these organs and tissues. Patients with bone-metastatic cancers face a grim prognosis characterized by short median survival time. Current treatments have proven insufficient, as they can only inhibit metastasis or tumor progression within the bone tissues rather than providing a curative solution. Gaining a more profound comprehension of the interplay between tumor cells and the bone microenvironment (BME) is of utmost importance in tackling this issue. This knowledge will pave the way for developing innovative diagnostic and therapeutic approaches. This review summarizes the mechanisms underlying bone metastasis and discusses the clinical aspects of this pathologic condition. Additionally, it highlights emerging therapeutic interventions aimed at enhancing the quality of life for patients affected by bone-metastatic cancers. By synthesizing current research, this review seeks to shed light on the complexities of bone metastasis and offer insights for future advancements in patient care. |
| first_indexed | 2024-03-08T16:07:26Z |
| format | Article |
| id | doaj.art-78b954f882f04992bdb39369aeee971e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T16:07:26Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-78b954f882f04992bdb39369aeee971e2024-01-08T04:44:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12604911260491Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancersHuanrong Lan0Bo Wu1Ketao Jin2Yefeng Chen3Department of Surgical Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, ChinaDepartment of Colorectal Surgery, Affiliated Jinhua Hosptial, Zhejiang University School of Medicine, Jinhua, Zhejiang, ChinaDepartment of Respiratory Medicine, Shaoxing People’s Hospital, Shaoxing, Zhejiang, ChinaEvidence demonstrated that bones, liver, and lungs are the most common metastasis sites in some human malignancies, especially in prostate and breast cancers. Bone is the third most frequent target for spreading tumor cells among these organs and tissues. Patients with bone-metastatic cancers face a grim prognosis characterized by short median survival time. Current treatments have proven insufficient, as they can only inhibit metastasis or tumor progression within the bone tissues rather than providing a curative solution. Gaining a more profound comprehension of the interplay between tumor cells and the bone microenvironment (BME) is of utmost importance in tackling this issue. This knowledge will pave the way for developing innovative diagnostic and therapeutic approaches. This review summarizes the mechanisms underlying bone metastasis and discusses the clinical aspects of this pathologic condition. Additionally, it highlights emerging therapeutic interventions aimed at enhancing the quality of life for patients affected by bone-metastatic cancers. By synthesizing current research, this review seeks to shed light on the complexities of bone metastasis and offer insights for future advancements in patient care.https://www.frontiersin.org/articles/10.3389/fendo.2023.1260491/fullbone remodelingmetastasistreatment-related neoplasmscancersbone microenvironment |
| spellingShingle | Huanrong Lan Bo Wu Ketao Jin Yefeng Chen Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers Frontiers in Endocrinology bone remodeling metastasis treatment-related neoplasms cancers bone microenvironment |
| title | Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers |
| title_full | Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers |
| title_fullStr | Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers |
| title_full_unstemmed | Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers |
| title_short | Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers |
| title_sort | beyond boundaries unraveling innovative approaches to combat bone metastatic cancers |
| topic | bone remodeling metastasis treatment-related neoplasms cancers bone microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1260491/full |
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