α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
Abstract Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart d...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01105-x |
| _version_ | 1798024940007456768 |
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| author | Tian Zhang Qiang Zheng Yike Fu Congkun Xie Gonglin Fan Yifan Wang Yongjun Wu Xiujun Cai Gaorong Han Xiang Li |
| author_facet | Tian Zhang Qiang Zheng Yike Fu Congkun Xie Gonglin Fan Yifan Wang Yongjun Wu Xiujun Cai Gaorong Han Xiang Li |
| author_sort | Tian Zhang |
| collection | DOAJ |
| description | Abstract Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe2O3@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design. Graphical Abstract |
| first_indexed | 2024-04-11T18:10:54Z |
| format | Article |
| id | doaj.art-78bbbef04bd04365a7bea062fb85818b |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T18:10:54Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-78bbbef04bd04365a7bea062fb85818b2022-12-22T04:10:07ZengBMCJournal of Nanobiotechnology1477-31552021-11-0119111410.1186/s12951-021-01105-xα-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidanceTian Zhang0Qiang Zheng1Yike Fu2Congkun Xie3Gonglin Fan4Yifan Wang5Yongjun Wu6Xiujun Cai7Gaorong Han8Xiang Li9State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang UniversityKey Laboratory of Endoscopic Technique Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang UniversityState Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang UniversityState Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang UniversityKey Laboratory of Endoscopic Technique Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang UniversityKey Laboratory of Endoscopic Technique Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang UniversityState Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang UniversityKey Laboratory of Endoscopic Technique Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang UniversityState Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang UniversityState Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang UniversityAbstract Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe2O3@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01105-xHeterostructureSonodynamic therapySelf-supplied oxygenTumor theranostic |
| spellingShingle | Tian Zhang Qiang Zheng Yike Fu Congkun Xie Gonglin Fan Yifan Wang Yongjun Wu Xiujun Cai Gaorong Han Xiang Li α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance Journal of Nanobiotechnology Heterostructure Sonodynamic therapy Self-supplied oxygen Tumor theranostic |
| title | α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance |
| title_full | α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance |
| title_fullStr | α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance |
| title_full_unstemmed | α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance |
| title_short | α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance |
| title_sort | α fe2o3 pt heterostructure particles to enable sonodynamic therapy with self supplied o2 and imaging guidance |
| topic | Heterostructure Sonodynamic therapy Self-supplied oxygen Tumor theranostic |
| url | https://doi.org/10.1186/s12951-021-01105-x |
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