Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.

Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.

Phosphoinositide 3-kinases (PI3Ks) are promising targets for therapeutic development in cancer. The class I PI3K isoform p110α has received considerable attention in oncology because the gene encoding p110α (PIK3CA) is frequently mutated in human cancer. However, little is known about the function o...

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Bibliographic Details
Main Authors:	Sung Su Yea, Lomon So, Sharmila Mallya, Jongdae Lee, Kamalakannan Rajasekaran, Subramaniam Malarkannan, David A Fruman
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4051752?pdf=render

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