NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma

NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma

Abstract The dynamic changes of RNA N6-methyladenosine (m6A) during cancer progression participate in various cellular processes. However, less is known about a possible direct connection between upstream regulator and m6A modification, and therefore affects oncogenic progression. Here, we have iden...

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Bibliographic Details
Main Authors: Zhongting Mei, Zhihua Shen, Jiaying Pu, Qian Liu, Guoxin Liu, Xuting He, Yang Wang, Jinrui Yue, Shiyu Ge, Tao Li, Ye Yuan, Lei Yang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Osteosarcoma
ac4C acetylation
m6A methylation
NAT10
Glycolysis
YTHDC1
Online Access:https://doi.org/10.1186/s12964-023-01321-y

Internet

https://doi.org/10.1186/s12964-023-01321-y

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