The Role of Oxidative Stress in TB Meningitis and Therapeutic Options
Meningitis is an inflammatory condition affecting the meninges surrounding the brain and spinal cord. Meningitis can be triggered by various factors, including infectious agents like viruses and bacteria and non-infectious contributors such as cancer or head injuries. The impact of meningitis on the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/12/3/50 |
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| author | John Dawi Aishvaryaa Shree Mohan Yura Misakyan Scarlet Affa Edgar Gonzalez Karim Hajjar David Nikoghosyan Sabrina Fardeheb Christopher Tuohino Vishwanath Venketaraman |
| author_facet | John Dawi Aishvaryaa Shree Mohan Yura Misakyan Scarlet Affa Edgar Gonzalez Karim Hajjar David Nikoghosyan Sabrina Fardeheb Christopher Tuohino Vishwanath Venketaraman |
| author_sort | John Dawi |
| collection | DOAJ |
| description | Meningitis is an inflammatory condition affecting the meninges surrounding the brain and spinal cord. Meningitis can be triggered by various factors, including infectious agents like viruses and bacteria and non-infectious contributors such as cancer or head injuries. The impact of meningitis on the central nervous system involves disruptions in the blood–brain barrier, cellular infiltrations, and structural alterations. The clinical features that differentiate between tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM) are discussed in this review and aid in accurate diagnosis. The intricate interplay of reactive oxygen species, ferroptosis, and reactive nitrogen species within the central nervous system reveals a promising field of research for innovative therapeutic strategies tailored to TBM. This review highlights the alternative treatments targeting oxidative stress-induced TBM and ferroptosis, providing potential avenues for intervention in the pathogenesis of this complex condition. |
| first_indexed | 2024-04-24T18:23:34Z |
| format | Article |
| id | doaj.art-78beee6ca7aa4efcaf9725c579baad87 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-04-24T18:23:34Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-78beee6ca7aa4efcaf9725c579baad872024-03-27T13:33:38ZengMDPI AGDiseases2079-97212024-02-011235010.3390/diseases12030050The Role of Oxidative Stress in TB Meningitis and Therapeutic OptionsJohn Dawi0Aishvaryaa Shree Mohan1Yura Misakyan2Scarlet Affa3Edgar Gonzalez4Karim Hajjar5David Nikoghosyan6Sabrina Fardeheb7Christopher Tuohino8Vishwanath Venketaraman9College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USALos Angeles Valley College, Valley Glen, CA 91401, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USACollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USAMeningitis is an inflammatory condition affecting the meninges surrounding the brain and spinal cord. Meningitis can be triggered by various factors, including infectious agents like viruses and bacteria and non-infectious contributors such as cancer or head injuries. The impact of meningitis on the central nervous system involves disruptions in the blood–brain barrier, cellular infiltrations, and structural alterations. The clinical features that differentiate between tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM) are discussed in this review and aid in accurate diagnosis. The intricate interplay of reactive oxygen species, ferroptosis, and reactive nitrogen species within the central nervous system reveals a promising field of research for innovative therapeutic strategies tailored to TBM. This review highlights the alternative treatments targeting oxidative stress-induced TBM and ferroptosis, providing potential avenues for intervention in the pathogenesis of this complex condition.https://www.mdpi.com/2079-9721/12/3/50tuberculous meningitisnon-tuberculous meningitisreactive oxygen speciesferroptosisoxidative stress-induced TB meningitis |
| spellingShingle | John Dawi Aishvaryaa Shree Mohan Yura Misakyan Scarlet Affa Edgar Gonzalez Karim Hajjar David Nikoghosyan Sabrina Fardeheb Christopher Tuohino Vishwanath Venketaraman The Role of Oxidative Stress in TB Meningitis and Therapeutic Options Diseases tuberculous meningitis non-tuberculous meningitis reactive oxygen species ferroptosis oxidative stress-induced TB meningitis |
| title | The Role of Oxidative Stress in TB Meningitis and Therapeutic Options |
| title_full | The Role of Oxidative Stress in TB Meningitis and Therapeutic Options |
| title_fullStr | The Role of Oxidative Stress in TB Meningitis and Therapeutic Options |
| title_full_unstemmed | The Role of Oxidative Stress in TB Meningitis and Therapeutic Options |
| title_short | The Role of Oxidative Stress in TB Meningitis and Therapeutic Options |
| title_sort | role of oxidative stress in tb meningitis and therapeutic options |
| topic | tuberculous meningitis non-tuberculous meningitis reactive oxygen species ferroptosis oxidative stress-induced TB meningitis |
| url | https://www.mdpi.com/2079-9721/12/3/50 |
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