Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation
Facilitated endogenous tissue engineering, as a facile and effective strategy, is emerging for use in bone tissue regeneration. However, the development of bioactive scaffolds with excellent osteo-inductivity to recruit endogenous stem cells homing and differentiation towards lesion areas remains an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/8/1023 |
| _version_ | 1797431832796463104 |
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| author | Yao Zhao Sinuo Zhao Zhengxin Ma Chunmei Ding Jingdi Chen Jianshu Li |
| author_facet | Yao Zhao Sinuo Zhao Zhengxin Ma Chunmei Ding Jingdi Chen Jianshu Li |
| author_sort | Yao Zhao |
| collection | DOAJ |
| description | Facilitated endogenous tissue engineering, as a facile and effective strategy, is emerging for use in bone tissue regeneration. However, the development of bioactive scaffolds with excellent osteo-inductivity to recruit endogenous stem cells homing and differentiation towards lesion areas remains an urgent problem. Chitosan (CS), with versatile qualities including good biocompatibility, biodegradability, and tunable physicochemical and biological properties is undergoing vigorously development in the field of bone repair. Based on this, the review focus on recent advances in chitosan-based scaffolds for facilitated endogenous bone regeneration. Initially, we introduced and compared the facilitated endogenous tissue engineering with traditional tissue engineering. Subsequently, the various CS-based bone repair scaffolds and their fabrication methods were briefly explored. Furthermore, the functional design of CS-based scaffolds in bone endogenous regeneration including biomolecular loading, inorganic nanomaterials hybridization, and physical stimulation was highlighted and discussed. Finally, the major challenges and further research directions of CS-based scaffolds were also elaborated. We hope that this review will provide valuable reference for further bone repair research in the future. |
| first_indexed | 2024-03-09T09:51:00Z |
| format | Article |
| id | doaj.art-78bf6ca156c6446ebca2d2c7d2512f13 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T09:51:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-78bf6ca156c6446ebca2d2c7d2512f132023-12-02T00:09:11ZengMDPI AGPharmaceuticals1424-82472022-08-01158102310.3390/ph15081023Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-GenerationYao Zhao0Sinuo Zhao1Zhengxin Ma2Chunmei Ding3Jingdi Chen4Jianshu Li5State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, ChinaState Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, ChinaState Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, ChinaState Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, ChinaMarine College, Shandong University, Weihai 264209, ChinaState Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, ChinaFacilitated endogenous tissue engineering, as a facile and effective strategy, is emerging for use in bone tissue regeneration. However, the development of bioactive scaffolds with excellent osteo-inductivity to recruit endogenous stem cells homing and differentiation towards lesion areas remains an urgent problem. Chitosan (CS), with versatile qualities including good biocompatibility, biodegradability, and tunable physicochemical and biological properties is undergoing vigorously development in the field of bone repair. Based on this, the review focus on recent advances in chitosan-based scaffolds for facilitated endogenous bone regeneration. Initially, we introduced and compared the facilitated endogenous tissue engineering with traditional tissue engineering. Subsequently, the various CS-based bone repair scaffolds and their fabrication methods were briefly explored. Furthermore, the functional design of CS-based scaffolds in bone endogenous regeneration including biomolecular loading, inorganic nanomaterials hybridization, and physical stimulation was highlighted and discussed. Finally, the major challenges and further research directions of CS-based scaffolds were also elaborated. We hope that this review will provide valuable reference for further bone repair research in the future.https://www.mdpi.com/1424-8247/15/8/1023facilitated endogenous tissue engineeringchitosanbioactive scaffoldfunctional designbone repair |
| spellingShingle | Yao Zhao Sinuo Zhao Zhengxin Ma Chunmei Ding Jingdi Chen Jianshu Li Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation Pharmaceuticals facilitated endogenous tissue engineering chitosan bioactive scaffold functional design bone repair |
| title | Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation |
| title_full | Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation |
| title_fullStr | Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation |
| title_full_unstemmed | Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation |
| title_short | Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation |
| title_sort | chitosan based scaffolds for facilitated endogenous bone re generation |
| topic | facilitated endogenous tissue engineering chitosan bioactive scaffold functional design bone repair |
| url | https://www.mdpi.com/1424-8247/15/8/1023 |
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