Relationship between thyroid dysfunction and dementia
Abstract Background Thyroid hormones are essential for normal development and function of the central nervous system. Thyroid dysfunction is associated with many neuropsychiatric disorders mainly cognitive impairment. Results We found a close correlation between thyroid status and cognitive dysfunct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-10-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43162-020-00003-2 |
| _version_ | 1818340749031243776 |
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| author | Ayman M. Elbadawy Ahmed E. Mansour Ibrahim A. Abdelrassoul Rasha O. Abdelmoneim |
| author_facet | Ayman M. Elbadawy Ahmed E. Mansour Ibrahim A. Abdelrassoul Rasha O. Abdelmoneim |
| author_sort | Ayman M. Elbadawy |
| collection | DOAJ |
| description | Abstract Background Thyroid hormones are essential for normal development and function of the central nervous system. Thyroid dysfunction is associated with many neuropsychiatric disorders mainly cognitive impairment. Results We found a close correlation between thyroid status and cognitive dysfunction. Serum FT3 levels decreased, whereas the serum thyroid-stimulating hormone (TSH) level increased, with the decline in cognitive functions. Furthermore, the TSH level showed a negative correlation with the Mini-Mental State Examination (MMSE) scores. We suggested that thyroid function was associated with cognitive impairments induced by subcortical ischemic vascular dementia (SIVD). Conclusion We found that thyroid dysfunction especially subclinical hypothyroidism is associated with cognitive impairment. Dementia increases more with more increase in TSH, and the MMSE score decreases with the increase of age. |
| first_indexed | 2024-12-13T15:47:50Z |
| format | Article |
| id | doaj.art-78bf99ed56b746f3881316df84817b8a |
| institution | Directory Open Access Journal |
| issn | 1110-7782 2090-9098 |
| language | English |
| last_indexed | 2024-12-13T15:47:50Z |
| publishDate | 2020-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-78bf99ed56b746f3881316df84817b8a2022-12-21T23:39:38ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982020-10-013211910.1186/s43162-020-00003-2Relationship between thyroid dysfunction and dementiaAyman M. Elbadawy0Ahmed E. Mansour1Ibrahim A. Abdelrassoul2Rasha O. Abdelmoneim3Department of Internal Medicine, Faculty of Medicine, Benha UniversityDepartment of Internal Medicine, Faculty of Medicine, Benha UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Benha UniversityDepartment of Internal Medicine, Faculty of Medicine, Benha UniversityAbstract Background Thyroid hormones are essential for normal development and function of the central nervous system. Thyroid dysfunction is associated with many neuropsychiatric disorders mainly cognitive impairment. Results We found a close correlation between thyroid status and cognitive dysfunction. Serum FT3 levels decreased, whereas the serum thyroid-stimulating hormone (TSH) level increased, with the decline in cognitive functions. Furthermore, the TSH level showed a negative correlation with the Mini-Mental State Examination (MMSE) scores. We suggested that thyroid function was associated with cognitive impairments induced by subcortical ischemic vascular dementia (SIVD). Conclusion We found that thyroid dysfunction especially subclinical hypothyroidism is associated with cognitive impairment. Dementia increases more with more increase in TSH, and the MMSE score decreases with the increase of age.http://link.springer.com/article/10.1186/s43162-020-00003-2TSHDementiaADVDFTDMMSE |
| spellingShingle | Ayman M. Elbadawy Ahmed E. Mansour Ibrahim A. Abdelrassoul Rasha O. Abdelmoneim Relationship between thyroid dysfunction and dementia The Egyptian Journal of Internal Medicine TSH Dementia AD VD FTD MMSE |
| title | Relationship between thyroid dysfunction and dementia |
| title_full | Relationship between thyroid dysfunction and dementia |
| title_fullStr | Relationship between thyroid dysfunction and dementia |
| title_full_unstemmed | Relationship between thyroid dysfunction and dementia |
| title_short | Relationship between thyroid dysfunction and dementia |
| title_sort | relationship between thyroid dysfunction and dementia |
| topic | TSH Dementia AD VD FTD MMSE |
| url | http://link.springer.com/article/10.1186/s43162-020-00003-2 |
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