| Summary: | Objective To investigate the value of neutrophil extracellular trap （NET） formation in predicting esophageal cancer distant metastasis. Methods A total of 60 patients diagnosed with esophageal cancer （25 cases of distant metastasis and 35 cases of non-distant metastasis） and 30 healthy volunteers were included in this prospective study. Peripheral blood was collected to detect the level of NET. Results The level of NET in the peripheral blood of patients with esophageal cancer distant metastasis was higher than those of their counterparts without distant metastasis and healthy volunteers. Logistic regression analysis showed that increased peripheral blood NET content was an independent risk factor for esophageal cancer distant metastasis （OR=1049.592, 95%CI： 24.313-45310.558）. Monitoring NET content could predict distant metastasis of esophageal cancer （AUC=0.37, 95%CI： 0.737-0.937）, and its predictive value was higher than that of the neutrophil-to-lymphocyte ratio （NLR）. However, the combination of NET and NLR improved the sensitivity and specificity of NETs in predicting esophageal cancer distant metastasis. Conclusions NET formation is a high risk factor for distant metastasis of esophageal cancer. Monitoring NET in the peripheral blood yields high predictive value for esophageal cancer distant metastasis. NETs combined with NLR can improve the predictive value of NET.
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