Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis
Objective To investigate the value of neutrophil extracellular trap （NET） formation in predicting esophageal cancer distant metastasis. Methods A total of 60 patients diagnosed with esophageal cancer （25 cases of distant metastasis and 35 cases of non-distant metastasis） and 30 healthy volunteers we...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-10-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1667718832879-807508321.pdf |
| _version_ | 1797986473417375744 |
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| author | Lin Jie, Qian Ji, Jiang Guojun, Chen Mingzhi |
| author_facet | Lin Jie, Qian Ji, Jiang Guojun, Chen Mingzhi |
| author_sort | Lin Jie, Qian Ji, Jiang Guojun, Chen Mingzhi |
| collection | DOAJ |
| description | Objective To investigate the value of neutrophil extracellular trap （NET） formation in predicting esophageal cancer distant metastasis. Methods A total of 60 patients diagnosed with esophageal cancer （25 cases of distant metastasis and 35 cases of non-distant metastasis） and 30 healthy volunteers were included in this prospective study. Peripheral blood was collected to detect the level of NET. Results The level of NET in the peripheral blood of patients with esophageal cancer distant metastasis was higher than those of their counterparts without distant metastasis and healthy volunteers. Logistic regression analysis showed that increased peripheral blood NET content was an independent risk factor for esophageal cancer distant metastasis （OR=1049.592, 95%CI： 24.313-45310.558）. Monitoring NET content could predict distant metastasis of esophageal cancer （AUC=0.37, 95%CI： 0.737-0.937）, and its predictive value was higher than that of the neutrophil-to-lymphocyte ratio （NLR）. However, the combination of NET and NLR improved the sensitivity and specificity of NETs in predicting esophageal cancer distant metastasis. Conclusions NET formation is a high risk factor for distant metastasis of esophageal cancer. Monitoring NET in the peripheral blood yields high predictive value for esophageal cancer distant metastasis. NETs combined with NLR can improve the predictive value of NET. |
| first_indexed | 2024-04-11T07:34:02Z |
| format | Article |
| id | doaj.art-78c06e282e934cb6888be9d4ebeac62b |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-11T07:34:02Z |
| publishDate | 2022-10-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-78c06e282e934cb6888be9d4ebeac62b2022-12-22T04:36:47ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-10-01531075175510.3969/j.issn.0253-9802.2022.10.009Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasisLin Jie, Qian Ji, Jiang Guojun, Chen Mingzhi0Department of Cardiac and Thoracic Surgery, the Affiliated Yixing Hospital of Jiangsu University, Wuxi 214299, ChinaObjective To investigate the value of neutrophil extracellular trap （NET） formation in predicting esophageal cancer distant metastasis. Methods A total of 60 patients diagnosed with esophageal cancer （25 cases of distant metastasis and 35 cases of non-distant metastasis） and 30 healthy volunteers were included in this prospective study. Peripheral blood was collected to detect the level of NET. Results The level of NET in the peripheral blood of patients with esophageal cancer distant metastasis was higher than those of their counterparts without distant metastasis and healthy volunteers. Logistic regression analysis showed that increased peripheral blood NET content was an independent risk factor for esophageal cancer distant metastasis （OR=1049.592, 95%CI： 24.313-45310.558）. Monitoring NET content could predict distant metastasis of esophageal cancer （AUC=0.37, 95%CI： 0.737-0.937）, and its predictive value was higher than that of the neutrophil-to-lymphocyte ratio （NLR）. However, the combination of NET and NLR improved the sensitivity and specificity of NETs in predicting esophageal cancer distant metastasis. Conclusions NET formation is a high risk factor for distant metastasis of esophageal cancer. Monitoring NET in the peripheral blood yields high predictive value for esophageal cancer distant metastasis. NETs combined with NLR can improve the predictive value of NET.https://www.xinyixue.cn/fileup/0253-9802/PDF/1667718832879-807508321.pdf|esophageal cancer|distant metastasis|neutrophil extracellular trap|neutrophil-to-lymphocyte ratio |
| spellingShingle | Lin Jie, Qian Ji, Jiang Guojun, Chen Mingzhi Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis Xin yixue |esophageal cancer|distant metastasis|neutrophil extracellular trap|neutrophil-to-lymphocyte ratio |
| title | Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis |
| title_full | Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis |
| title_fullStr | Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis |
| title_full_unstemmed | Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis |
| title_short | Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis |
| title_sort | value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis |
| topic | |esophageal cancer|distant metastasis|neutrophil extracellular trap|neutrophil-to-lymphocyte ratio |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1667718832879-807508321.pdf |
| work_keys_str_mv | AT linjieqianjijiangguojunchenmingzhi valueofneutrophilextracellulartrapformationinpredictingesophagealcancerdistantmetastasis |