INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE
The efficiency of using co-trimoxazole for treatment of mice infected with tuberculous mycobacteria with extensive drug resistance and supposed sensitivity to co-trimoxazole have been investigated.The study of 78 clinical cultures of tuberculous mycobacteria has demonstrated that drug resistance to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-02-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/976 |
| _version_ | 1797703521841184768 |
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| author | S. A. Popov G. N. Mozhokina S. A. Kosenkov N. A. Elistratova T. P. Sabgayda |
| author_facet | S. A. Popov G. N. Mozhokina S. A. Kosenkov N. A. Elistratova T. P. Sabgayda |
| author_sort | S. A. Popov |
| collection | DOAJ |
| description | The efficiency of using co-trimoxazole for treatment of mice infected with tuberculous mycobacteria with extensive drug resistance and supposed sensitivity to co-trimoxazole have been investigated.The study of 78 clinical cultures of tuberculous mycobacteria has demonstrated that drug resistance to first line drugs (cases with multiple drug resistance – MDR) can be accompanied by the expansion of polymorphism in the part of drug susceptibility to co-trimoxazole, thus this drug can be used as an additional drug in the treatment of M/XDR tuberculosis patients. Using co-trimoxazole as an additional drug to isoniazid in the model of generalized tuberculosis in mice infected with Beijing strain with XDR reduced the bacterial load of the lungs by 10 times.Detail evaluation of drug susceptibility/resistance of tuberculous mycobacteria to the additional drug of co-trimoxazole and investigation of the interaction of this drug with other agents included into treatment regimens IV and V can form the basis for improvement of treatment regimens for M/XDR tuberculosis patients with specification of doses and frequency of drug in-takes for each specific case. |
| first_indexed | 2024-03-12T05:05:45Z |
| format | Article |
| id | doaj.art-78c22f594bac47ad8814bf78ae11be81 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T05:05:45Z |
| publishDate | 2017-02-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-78c22f594bac47ad8814bf78ae11be812023-09-03T08:57:17ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062017-02-01952515810.21292/2075-1230-2017-95-2-51-58976INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCES. A. Popov0G. N. Mozhokina1S. A. Kosenkov2N. A. Elistratova3T. P. Sabgayda4НИИ фтизиопульмонологии ФГБОУ ВО «Первый МГМУ им. И. М. Сеченова» МЗ РФНИИ фтизиопульмонологии ФГБОУ ВО «Первый МГМУ им. И. М. Сеченова» МЗ РФНИИ фтизиопульмонологии ФГБОУ ВО «Первый МГМУ им. И. М. Сеченова» МЗ РФНИИ фтизиопульмонологии ФГБОУ ВО «Первый МГМУ им. И. М. Сеченова» МЗ РФНИИ фтизиопульмонологии ФГБОУ ВО «Первый МГМУ им. И. М. Сеченова» МЗ РФ; ФГБУ «Центральный НИИ организации и информатизации здравоохранения» МЗ РФThe efficiency of using co-trimoxazole for treatment of mice infected with tuberculous mycobacteria with extensive drug resistance and supposed sensitivity to co-trimoxazole have been investigated.The study of 78 clinical cultures of tuberculous mycobacteria has demonstrated that drug resistance to first line drugs (cases with multiple drug resistance – MDR) can be accompanied by the expansion of polymorphism in the part of drug susceptibility to co-trimoxazole, thus this drug can be used as an additional drug in the treatment of M/XDR tuberculosis patients. Using co-trimoxazole as an additional drug to isoniazid in the model of generalized tuberculosis in mice infected with Beijing strain with XDR reduced the bacterial load of the lungs by 10 times.Detail evaluation of drug susceptibility/resistance of tuberculous mycobacteria to the additional drug of co-trimoxazole and investigation of the interaction of this drug with other agents included into treatment regimens IV and V can form the basis for improvement of treatment regimens for M/XDR tuberculosis patients with specification of doses and frequency of drug in-takes for each specific case.https://www.tibl-journal.com/jour/article/view/976экспериментальный туберкулез у мышейтуберкулез с млу/шлу возбудителялекарственная чувствительность m. tuberculosis к ко-тримоксазолу |
| spellingShingle | S. A. Popov G. N. Mozhokina S. A. Kosenkov N. A. Elistratova T. P. Sabgayda INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE Туберкулез и болезни лёгких экспериментальный туберкулез у мышей туберкулез с млу/шлу возбудителя лекарственная чувствительность m. tuberculosis к ко-тримоксазолу |
| title | INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE |
| title_full | INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE |
| title_fullStr | INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE |
| title_full_unstemmed | INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE |
| title_short | INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE |
| title_sort | investigation of co trimoxazole efficiency using the experimental tuberculosis model in mice caused by tuberculous mycobacteria with extensive drug resistance |
| topic | экспериментальный туберкулез у мышей туберкулез с млу/шлу возбудителя лекарственная чувствительность m. tuberculosis к ко-тримоксазолу |
| url | https://www.tibl-journal.com/jour/article/view/976 |
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