Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer

Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer

SMURF2, an E3 ubiquitin ligase and suggested tumor suppressor, operates in normal cells to prevent genomic instability and carcinogenesis. However, the mechanisms underlying SMURF2 inactivation in human malignancies remain elusive, as <i>SMURF2</i> is rarely found mutated or deleted in c...

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Bibliographic Details
Main Authors: Andrea Emanuelli, Dhanoop Manikoth Ayyathan, Praveen Koganti, Pooja Anil Shah, Liat Apel-Sarid, Biagio Paolini, Rajesh Detroja, Milana Frenkel-Morgenstern, Michael Blank
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
SMURF2
prostate and breast cancer
gene and protein expression
molecular localization
interactome
Online Access:https://www.mdpi.com/2072-6694/11/4/556

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