Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial
Abstract Persistent post-concussion syndrome (PPCS) is a common and significant morbidity among children following traumatic brain injury (TBI) and the evidence for effective PPCS treatments remains limited. Recent studies have shown the beneficial effects of hyperbaric oxygen therapy (HBOT) in PPCS...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19395-y |
| _version_ | 1798001546087104512 |
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| author | Amir Hadanny Merav Catalogna Slava Yaniv Orit Stolar Lynn Rothstein Adi Shabi Gil Suzin Efrat Sasson Erez Lang Shachar Finci Nir Polak Gregory Fishlev Ruth Tock Harpaz Moran Adler Ron-El Goldman Yonatan Zemel Yair Bechor Shai Efrati |
| author_facet | Amir Hadanny Merav Catalogna Slava Yaniv Orit Stolar Lynn Rothstein Adi Shabi Gil Suzin Efrat Sasson Erez Lang Shachar Finci Nir Polak Gregory Fishlev Ruth Tock Harpaz Moran Adler Ron-El Goldman Yonatan Zemel Yair Bechor Shai Efrati |
| author_sort | Amir Hadanny |
| collection | DOAJ |
| description | Abstract Persistent post-concussion syndrome (PPCS) is a common and significant morbidity among children following traumatic brain injury (TBI) and the evidence for effective PPCS treatments remains limited. Recent studies have shown the beneficial effects of hyperbaric oxygen therapy (HBOT) in PPCS adult patients. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT) on children (age 8–15) suffering from PPCS from mild-moderate TBI events six months to 10 years prior. Twenty-five children were randomized to receive 60 daily sessions of HBOT (n = 15) or sham (n = 10) treatments. Following HBOT, there was a significant increase in cognitive function including the general cognitive score (d = 0.598, p = 0.01), memory (d = 0.480, p = 0.02), executive function (d = 0.739, p = 0.003), PPCS symptoms including emotional score (p = 0.04, d = – 0.676), behavioral symptoms including hyperactivity (d = 0.244, p = 0.03), global executive composite score (d = 0.528, p = 0.001), planning/organizing score (d = 1.09, p = 0.007). Clinical outcomes correlated with significant improvements in brain MRI microstructural changes in the insula, supramarginal, lingual, inferior frontal and fusiform gyri. The study suggests that HBOT improves both cognitive and behavioral function, PPCS symptoms, and quality of life in pediatric PPCS patients at the chronic stage, even years after injury. Additional data is needed to optimize the protocol and to characterize the children who can benefit the most. |
| first_indexed | 2024-04-11T11:37:57Z |
| format | Article |
| id | doaj.art-78c3b98835bd4d09bc53084dfa988b89 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T11:37:57Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-78c3b98835bd4d09bc53084dfa988b892022-12-22T04:25:55ZengNature PortfolioScientific Reports2045-23222022-09-0112111610.1038/s41598-022-19395-yHyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trialAmir Hadanny0Merav Catalogna1Slava Yaniv2Orit Stolar3Lynn Rothstein4Adi Shabi5Gil Suzin6Efrat Sasson7Erez Lang8Shachar Finci9Nir Polak10Gregory Fishlev11Ruth Tock Harpaz12Moran Adler13Ron-El Goldman14Yonatan Zemel15Yair Bechor16Shai Efrati17Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterAbstract Persistent post-concussion syndrome (PPCS) is a common and significant morbidity among children following traumatic brain injury (TBI) and the evidence for effective PPCS treatments remains limited. Recent studies have shown the beneficial effects of hyperbaric oxygen therapy (HBOT) in PPCS adult patients. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT) on children (age 8–15) suffering from PPCS from mild-moderate TBI events six months to 10 years prior. Twenty-five children were randomized to receive 60 daily sessions of HBOT (n = 15) or sham (n = 10) treatments. Following HBOT, there was a significant increase in cognitive function including the general cognitive score (d = 0.598, p = 0.01), memory (d = 0.480, p = 0.02), executive function (d = 0.739, p = 0.003), PPCS symptoms including emotional score (p = 0.04, d = – 0.676), behavioral symptoms including hyperactivity (d = 0.244, p = 0.03), global executive composite score (d = 0.528, p = 0.001), planning/organizing score (d = 1.09, p = 0.007). Clinical outcomes correlated with significant improvements in brain MRI microstructural changes in the insula, supramarginal, lingual, inferior frontal and fusiform gyri. The study suggests that HBOT improves both cognitive and behavioral function, PPCS symptoms, and quality of life in pediatric PPCS patients at the chronic stage, even years after injury. Additional data is needed to optimize the protocol and to characterize the children who can benefit the most.https://doi.org/10.1038/s41598-022-19395-y |
| spellingShingle | Amir Hadanny Merav Catalogna Slava Yaniv Orit Stolar Lynn Rothstein Adi Shabi Gil Suzin Efrat Sasson Erez Lang Shachar Finci Nir Polak Gregory Fishlev Ruth Tock Harpaz Moran Adler Ron-El Goldman Yonatan Zemel Yair Bechor Shai Efrati Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial Scientific Reports |
| title | Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial |
| title_full | Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial |
| title_fullStr | Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial |
| title_full_unstemmed | Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial |
| title_short | Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial |
| title_sort | hyperbaric oxygen therapy in children with post concussion syndrome improves cognitive and behavioral function a randomized controlled trial |
| url | https://doi.org/10.1038/s41598-022-19395-y |
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