Data supporting the role of Fyn in initiating myelination in the peripheral nervous system
Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) “Phosphorylation of cytohesin-1 by Fyn...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-06-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916302049 |
| _version_ | 1819212904312864768 |
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| author | Yuki Miyamoto Moe Tamano Tomohiro Torii Kazuko Kawahara Kazuaki Nakamura Akito Tanoue Shuji Takada Junji Yamauchi |
| author_facet | Yuki Miyamoto Moe Tamano Tomohiro Torii Kazuko Kawahara Kazuaki Nakamura Akito Tanoue Shuji Takada Junji Yamauchi |
| author_sort | Yuki Miyamoto |
| collection | DOAJ |
| description | Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) “Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2015 [1])”. Herein we provide the data regarding myelination-related protein markers and myelin ultrastructure in transgenic mice. Keywords: Fyn, Myelination, Peripheral nervous system, Myelin marker protein, Signaling |
| first_indexed | 2024-12-23T06:50:22Z |
| format | Article |
| id | doaj.art-78c56ccb6aef4be898a2ae70ffd0d23b |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-23T06:50:22Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-78c56ccb6aef4be898a2ae70ffd0d23b2022-12-21T17:56:27ZengElsevierData in Brief2352-34092016-06-01710981105Data supporting the role of Fyn in initiating myelination in the peripheral nervous systemYuki Miyamoto0Moe Tamano1Tomohiro Torii2Kazuko Kawahara3Kazuaki Nakamura4Akito Tanoue5Shuji Takada6Junji Yamauchi7Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, JapanDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, JapanDepartment of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, JapanDepartment of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, JapanDepartment of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, JapanDepartment of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, JapanDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, JapanDepartment of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, Japan; Correspondence to: Molecular Pharmacology Group, Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. Tel.: +81 3 5494 7120x4670; fax: +81 3 5494 7057.Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) “Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2015 [1])”. Herein we provide the data regarding myelination-related protein markers and myelin ultrastructure in transgenic mice. Keywords: Fyn, Myelination, Peripheral nervous system, Myelin marker protein, Signalinghttp://www.sciencedirect.com/science/article/pii/S2352340916302049 |
| spellingShingle | Yuki Miyamoto Moe Tamano Tomohiro Torii Kazuko Kawahara Kazuaki Nakamura Akito Tanoue Shuji Takada Junji Yamauchi Data supporting the role of Fyn in initiating myelination in the peripheral nervous system Data in Brief |
| title | Data supporting the role of Fyn in initiating myelination in the peripheral nervous system |
| title_full | Data supporting the role of Fyn in initiating myelination in the peripheral nervous system |
| title_fullStr | Data supporting the role of Fyn in initiating myelination in the peripheral nervous system |
| title_full_unstemmed | Data supporting the role of Fyn in initiating myelination in the peripheral nervous system |
| title_short | Data supporting the role of Fyn in initiating myelination in the peripheral nervous system |
| title_sort | data supporting the role of fyn in initiating myelination in the peripheral nervous system |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916302049 |
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