Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance. In that regard, flexible nucleoside analogues know...

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Bibliographic Details
Main Authors: Mary K. Yates, Payel Chatterjee, Mike Flint, Yafet Arefeayne, Damjan Makuc, Janez Plavec, Christina F. Spiropoulou, Katherine L. Seley-Radtke
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
nucleoside
SAR
filovirus
flavivirus
fleximers
Online Access:https://www.mdpi.com/1420-3049/24/17/3184

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