Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster
Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2013-06-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585&lng=en&tlng=en |
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| author | LEONARDO P. FRANCHI NILZA N. GUIMARAES LAISE R. DE ANDRADE HELOISA H.R. DE ANDRADE MAURICIO LEHMANN RAFAEL R. DIHL KENYA S. CUNHA |
| author_facet | LEONARDO P. FRANCHI NILZA N. GUIMARAES LAISE R. DE ANDRADE HELOISA H.R. DE ANDRADE MAURICIO LEHMANN RAFAEL R. DIHL KENYA S. CUNHA |
| author_sort | LEONARDO P. FRANCHI |
| collection | DOAJ |
| description | Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ. |
| first_indexed | 2024-04-12T18:43:28Z |
| format | Article |
| id | doaj.art-78c8715d1aac40e8b79700a8f9be114f |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-12T18:43:28Z |
| publishDate | 2013-06-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-78c8715d1aac40e8b79700a8f9be114f2022-12-22T03:20:42ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902013-06-0185258559410.1590/S0001-37652013000200008S0001-37652013000200585Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogasterLEONARDO P. FRANCHINILZA N. GUIMARAESLAISE R. DE ANDRADEHELOISA H.R. DE ANDRADEMAURICIO LEHMANNRAFAEL R. DIHLKENYA S. CUNHANoni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585&lng=en&tlng=enantigenotoxicidadedoxorrubicinamitomicina CSMARTsuco de noni |
| spellingShingle | LEONARDO P. FRANCHI NILZA N. GUIMARAES LAISE R. DE ANDRADE HELOISA H.R. DE ANDRADE MAURICIO LEHMANN RAFAEL R. DIHL KENYA S. CUNHA Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster Anais da Academia Brasileira de Ciências antigenotoxicidade doxorrubicina mitomicina C SMART suco de noni |
| title | Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster |
| title_full | Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster |
| title_fullStr | Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster |
| title_full_unstemmed | Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster |
| title_short | Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster |
| title_sort | antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of drosophila melanogaster |
| topic | antigenotoxicidade doxorrubicina mitomicina C SMART suco de noni |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585&lng=en&tlng=en |
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