A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis
Non-adherence to anti-tubercular therapy Mycobacterium tuberculosis infection can lead to treatment failure and even the development of drug resistance. In this work, the authors develop a long-acting delivery system of the anti-tuberculosis drug rifabutin and assess translational potential in vivo.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32043-3 |
| _version_ | 1828154352246718464 |
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| author | Manse Kim Claire E. Johnson Alan A. Schmalstig Ayano Annis Sarah E. Wessel Brian Van Horn Amanda Schauer Agata A. Exner Jason E. Stout Angela Wahl Miriam Braunstein J. Victor Garcia Martina Kovarova |
| author_facet | Manse Kim Claire E. Johnson Alan A. Schmalstig Ayano Annis Sarah E. Wessel Brian Van Horn Amanda Schauer Agata A. Exner Jason E. Stout Angela Wahl Miriam Braunstein J. Victor Garcia Martina Kovarova |
| author_sort | Manse Kim |
| collection | DOAJ |
| description | Non-adherence to anti-tubercular therapy Mycobacterium tuberculosis infection can lead to treatment failure and even the development of drug resistance. In this work, the authors develop a long-acting delivery system of the anti-tuberculosis drug rifabutin and assess translational potential in vivo. |
| first_indexed | 2024-04-11T22:38:40Z |
| format | Article |
| id | doaj.art-78ca0bb18972453d8ccd4f196de8996e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T22:38:40Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-78ca0bb18972453d8ccd4f196de8996e2022-12-22T03:59:06ZengNature PortfolioNature Communications2041-17232022-08-0113111610.1038/s41467-022-32043-3A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosisManse Kim0Claire E. Johnson1Alan A. Schmalstig2Ayano Annis3Sarah E. Wessel4Brian Van Horn5Amanda Schauer6Agata A. Exner7Jason E. Stout8Angela Wahl9Miriam Braunstein10J. Victor Garcia11Martina Kovarova12International Center for the Advancement of Translational Science, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel HillUNC Eshelman School of Pharmacy, University of North Carolina at Chapel HillUNC Eshelman School of Pharmacy, University of North Carolina at Chapel HillDepartment of Radiology, Case Western Reserve UniversityDivision of Infectious Diseases, Department of Medicine, Duke UniversityInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, University of North Carolina at Chapel HillNon-adherence to anti-tubercular therapy Mycobacterium tuberculosis infection can lead to treatment failure and even the development of drug resistance. In this work, the authors develop a long-acting delivery system of the anti-tuberculosis drug rifabutin and assess translational potential in vivo.https://doi.org/10.1038/s41467-022-32043-3 |
| spellingShingle | Manse Kim Claire E. Johnson Alan A. Schmalstig Ayano Annis Sarah E. Wessel Brian Van Horn Amanda Schauer Agata A. Exner Jason E. Stout Angela Wahl Miriam Braunstein J. Victor Garcia Martina Kovarova A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis Nature Communications |
| title | A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis |
| title_full | A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis |
| title_fullStr | A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis |
| title_full_unstemmed | A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis |
| title_short | A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis |
| title_sort | long acting formulation of rifabutin is effective for prevention and treatment of mycobacterium tuberculosis |
| url | https://doi.org/10.1038/s41467-022-32043-3 |
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