Effects of chronic fentanyl administration on behavioral characteristics of mice
Abstract Background Fentanyl, a synthetic opioid categorized as a narcotic analgesic, has a 100‐ to 200‐fold stronger effect than most opioids, such as morphine. Fatal accidents due to chronic use and abuse of fentanyl are a worldwide social problem. One reason for the abuse of fentanyl is its psych...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-03-01
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| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12040 |
| _version_ | 1811185616459661312 |
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| author | Kazuki Fujii Yumie Koshidaka Mayumi Adachi Keizo Takao |
| author_facet | Kazuki Fujii Yumie Koshidaka Mayumi Adachi Keizo Takao |
| author_sort | Kazuki Fujii |
| collection | DOAJ |
| description | Abstract Background Fentanyl, a synthetic opioid categorized as a narcotic analgesic, has a 100‐ to 200‐fold stronger effect than most opioids, such as morphine. Fatal accidents due to chronic use and abuse of fentanyl are a worldwide social problem. One reason for the abuse of fentanyl is its psychostimulant effects that could induce behavioral changes. The effects of chronic fentanyl administration on behavior, however, are unclear. Methods Adult male C57BL/6J mice were chronically administered fentanyl (0.03 or 0.3 mg/kg/d i.p.), and various behaviors were assessed using a behavioral test battery. Results Mice chronically administered a high dose of fentanyl (0.3 mg/kg/d) exhibited decreased anxiety‐like behavior as assessed by the open field and elevated plus maze tests. On the other hand, interruption of fentanyl administration led to increased anxiety‐like behavior as observed in the light and dark transition test. The hot plate test revealed that chronic administration of fentanyl reduced pain sensitivity. High‐dose chronic fentanyl administration reduced the locomotor stimulatory effects of cocaine. The results, however, failed to reach the threshold for study‐wide statistical significance. Conclusion Chronic fentanyl administration induces some behavioral changes in mice. Although further studies are needed to clarify the underlying mechanisms of the behavioral effects of chronic fentanyl administration, our findings suggest that fentanyl is safe under properly controlled conditions. |
| first_indexed | 2024-04-11T13:33:19Z |
| format | Article |
| id | doaj.art-78cab4a699fc4de9882b92b411fd15cd |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-11T13:33:19Z |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-78cab4a699fc4de9882b92b411fd15cd2022-12-22T04:21:43ZengWileyNeuropsychopharmacology Reports2574-173X2019-03-01391173510.1002/npr2.12040Effects of chronic fentanyl administration on behavioral characteristics of miceKazuki Fujii0Yumie Koshidaka1Mayumi Adachi2Keizo Takao3Department of Behavioral Physiology Graduate School of Innovative Life Science University of Toyama Toyama JapanLife Science Research Center University of Toyama Toyama JapanLife Science Research Center University of Toyama Toyama JapanDepartment of Behavioral Physiology Graduate School of Innovative Life Science University of Toyama Toyama JapanAbstract Background Fentanyl, a synthetic opioid categorized as a narcotic analgesic, has a 100‐ to 200‐fold stronger effect than most opioids, such as morphine. Fatal accidents due to chronic use and abuse of fentanyl are a worldwide social problem. One reason for the abuse of fentanyl is its psychostimulant effects that could induce behavioral changes. The effects of chronic fentanyl administration on behavior, however, are unclear. Methods Adult male C57BL/6J mice were chronically administered fentanyl (0.03 or 0.3 mg/kg/d i.p.), and various behaviors were assessed using a behavioral test battery. Results Mice chronically administered a high dose of fentanyl (0.3 mg/kg/d) exhibited decreased anxiety‐like behavior as assessed by the open field and elevated plus maze tests. On the other hand, interruption of fentanyl administration led to increased anxiety‐like behavior as observed in the light and dark transition test. The hot plate test revealed that chronic administration of fentanyl reduced pain sensitivity. High‐dose chronic fentanyl administration reduced the locomotor stimulatory effects of cocaine. The results, however, failed to reach the threshold for study‐wide statistical significance. Conclusion Chronic fentanyl administration induces some behavioral changes in mice. Although further studies are needed to clarify the underlying mechanisms of the behavioral effects of chronic fentanyl administration, our findings suggest that fentanyl is safe under properly controlled conditions.https://doi.org/10.1002/npr2.12040addictionbehavioral test batterycocainefentanylopioid |
| spellingShingle | Kazuki Fujii Yumie Koshidaka Mayumi Adachi Keizo Takao Effects of chronic fentanyl administration on behavioral characteristics of mice Neuropsychopharmacology Reports addiction behavioral test battery cocaine fentanyl opioid |
| title | Effects of chronic fentanyl administration on behavioral characteristics of mice |
| title_full | Effects of chronic fentanyl administration on behavioral characteristics of mice |
| title_fullStr | Effects of chronic fentanyl administration on behavioral characteristics of mice |
| title_full_unstemmed | Effects of chronic fentanyl administration on behavioral characteristics of mice |
| title_short | Effects of chronic fentanyl administration on behavioral characteristics of mice |
| title_sort | effects of chronic fentanyl administration on behavioral characteristics of mice |
| topic | addiction behavioral test battery cocaine fentanyl opioid |
| url | https://doi.org/10.1002/npr2.12040 |
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