Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients
Immune reconstitution inflammatory syndrome (IRIS) is a consequence of exaggerated and dysregulated host’s inflammatory response to invading microorganism, leading to uncontrolled inflammatory reactions. IRIS associated with tuberculosis (TB) is well recognized among human immunodeficiency virus (HI...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-03-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/thoracic-manifestations-of-paradoxical-immune-reco/55891
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| _version_ | 1797691151620243456 |
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| author | Prapaporn Pornsuriyasak Thitiporn Suwatanapongched |
| author_facet | Prapaporn Pornsuriyasak Thitiporn Suwatanapongched |
| author_sort | Prapaporn Pornsuriyasak |
| collection | DOAJ |
| description | Immune reconstitution inflammatory syndrome (IRIS) is a consequence of exaggerated and dysregulated host’s inflammatory response to invading microorganism, leading to uncontrolled inflammatory reactions. IRIS associated with tuberculosis (TB) is well recognized among human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy, but it is less common among HIV-negative patients. IRIS can manifest as a paradoxical worsening or recurring of preexisting tuberculous lesions or development of new lesions despite successful antituberculous treatment. Hence, the condition might be misdiagnosed as superimposed infections, treatment failure, or relapse of TB. This pictorial essay reviewed diagnostic criteria and various thoracic manifestations of the paradoxical form of TB-associated IRIS (TB-IRIS) that might aid in early recognition of this clinical entity among HIV-negative patients. The treatment and outcomes of TB-IRIS were also discussed. |
| first_indexed | 2024-03-12T02:10:11Z |
| format | Article |
| id | doaj.art-78d22e9b859a405298531d8aa046d56a |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:10:11Z |
| publishDate | 2015-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-78d22e9b859a405298531d8aa046d56a2023-09-06T13:50:03ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122015-03-0121213413910.5152/dir.2014.1421213049054Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patientsPrapaporn Pornsuriyasak0Thitiporn Suwatanapongched1 Division of Pulmonary and Critical Care, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Division of Diagnostic Radiology, Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Immune reconstitution inflammatory syndrome (IRIS) is a consequence of exaggerated and dysregulated host’s inflammatory response to invading microorganism, leading to uncontrolled inflammatory reactions. IRIS associated with tuberculosis (TB) is well recognized among human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy, but it is less common among HIV-negative patients. IRIS can manifest as a paradoxical worsening or recurring of preexisting tuberculous lesions or development of new lesions despite successful antituberculous treatment. Hence, the condition might be misdiagnosed as superimposed infections, treatment failure, or relapse of TB. This pictorial essay reviewed diagnostic criteria and various thoracic manifestations of the paradoxical form of TB-associated IRIS (TB-IRIS) that might aid in early recognition of this clinical entity among HIV-negative patients. The treatment and outcomes of TB-IRIS were also discussed. http://www.dirjournal.org/archives/archive-detail/article-preview/thoracic-manifestations-of-paradoxical-immune-reco/55891 |
| spellingShingle | Prapaporn Pornsuriyasak Thitiporn Suwatanapongched Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients Diagnostic and Interventional Radiology |
| title | Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients |
| title_full | Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients |
| title_fullStr | Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients |
| title_full_unstemmed | Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients |
| title_short | Thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in HIV-negative patients |
| title_sort | thoracic manifestations of paradoxical immune reconstitution inflammatory syndrome during or after antituberculous therapy in hiv negative patients |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/thoracic-manifestations-of-paradoxical-immune-reco/55891
|
| work_keys_str_mv | AT prapapornpornsuriyasak thoracicmanifestationsofparadoxicalimmunereconstitutioninflammatorysyndromeduringorafterantituberculoustherapyinhivnegativepatients AT thitipornsuwatanapongched thoracicmanifestationsofparadoxicalimmunereconstitutioninflammatorysyndromeduringorafterantituberculoustherapyinhivnegativepatients |