Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery
The purpose of the present study was to test whether the addition of cisatracurium in combination with propofol and sevoflurane would result in a change in doses of used anesthetic drugs. Ten dogs (Group A) undergoing elective unilateral mastectomy surgery were included in the study. To induce and m...
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MDPI AG
2022-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/22/3134 |
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| author | Claudia Interlandi Simona Di Pietro Giovanna L. Costa Filippo Spadola Nicola M. Iannelli Daniele Macrì Vincenzo Ferrantelli Francesco Macrì |
| author_facet | Claudia Interlandi Simona Di Pietro Giovanna L. Costa Filippo Spadola Nicola M. Iannelli Daniele Macrì Vincenzo Ferrantelli Francesco Macrì |
| author_sort | Claudia Interlandi |
| collection | DOAJ |
| description | The purpose of the present study was to test whether the addition of cisatracurium in combination with propofol and sevoflurane would result in a change in doses of used anesthetic drugs. Ten dogs (Group A) undergoing elective unilateral mastectomy surgery were included in the study. To induce and maintain anesthesia, subjects received propofol and sevoflurane at varying doses; analgesia was performed with remifentanil. After three months, the same subjects (Group B) underwent contralateral mastectomy and received the same anesthetic protocol with the addition of cisatracurium at a dosage of 0.2 mg/kg<sup>−1</sup>. The following parameters were monitored during anesthesia: heart rate, systolic blood pressure, end-tidal CO<sub>2</sub>, oxygen saturation, halogenate requirement, and rectal temperature at baseline (T<sup>0</sup>), induction (T<sup>1</sup>), 5 (T<sup>5</sup>), 10 (T<sup>10</sup>), 15 (T<sup>15</sup>), 20 (T<sup>20</sup>), 25 (T<sup>25</sup>), 30 (T<sup>30</sup>), and 35 (T<sup>35</sup>) time points. In Group A, halogenate requirement was reduced at all the time points other than T1 (<i>p</i> < 0.001); in Group B, the percentage of halogenate requirement was already reduced at T<sup>1</sup> and remained constant during the experimental period, showing no significant intragroup differences. The dose requirements of sevoflurane and propofol varied significantly between the two groups, with significantly lower dosages in the Group B (the cisatracurium-treated group). Moreover, patients treated with cisatracurium showed a stable anesthetic plan. The nondepolarizing-muscle-relaxant cisatracurium besylate could be considered a useful adjunct to anesthetic protocols. |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T18:31:18Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-78d564be732d4401b388715b4bf101ce2023-11-24T07:28:47ZengMDPI AGAnimals2076-26152022-11-011222313410.3390/ani12223134Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy SurgeryClaudia Interlandi0Simona Di Pietro1Giovanna L. Costa2Filippo Spadola3Nicola M. Iannelli4Daniele Macrì5Vincenzo Ferrantelli6Francesco Macrì7Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Via Palatucci Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Via Palatucci Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Via Palatucci Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Via Palatucci Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Via Palatucci Annunziata, 98168 Messina, ItalyZooprophylactic Institute, Via Gino Marinuzzi 3, 90100 Palermo, ItalyZooprophylactic Institute, Via Gino Marinuzzi 3, 90100 Palermo, ItalyDepartment of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Via Palatucci Annunziata, 98168 Messina, ItalyThe purpose of the present study was to test whether the addition of cisatracurium in combination with propofol and sevoflurane would result in a change in doses of used anesthetic drugs. Ten dogs (Group A) undergoing elective unilateral mastectomy surgery were included in the study. To induce and maintain anesthesia, subjects received propofol and sevoflurane at varying doses; analgesia was performed with remifentanil. After three months, the same subjects (Group B) underwent contralateral mastectomy and received the same anesthetic protocol with the addition of cisatracurium at a dosage of 0.2 mg/kg<sup>−1</sup>. The following parameters were monitored during anesthesia: heart rate, systolic blood pressure, end-tidal CO<sub>2</sub>, oxygen saturation, halogenate requirement, and rectal temperature at baseline (T<sup>0</sup>), induction (T<sup>1</sup>), 5 (T<sup>5</sup>), 10 (T<sup>10</sup>), 15 (T<sup>15</sup>), 20 (T<sup>20</sup>), 25 (T<sup>25</sup>), 30 (T<sup>30</sup>), and 35 (T<sup>35</sup>) time points. In Group A, halogenate requirement was reduced at all the time points other than T1 (<i>p</i> < 0.001); in Group B, the percentage of halogenate requirement was already reduced at T<sup>1</sup> and remained constant during the experimental period, showing no significant intragroup differences. The dose requirements of sevoflurane and propofol varied significantly between the two groups, with significantly lower dosages in the Group B (the cisatracurium-treated group). Moreover, patients treated with cisatracurium showed a stable anesthetic plan. The nondepolarizing-muscle-relaxant cisatracurium besylate could be considered a useful adjunct to anesthetic protocols.https://www.mdpi.com/2076-2615/12/22/3134cisatracurium besylatepropofolsevofluranedogsurgery |
| spellingShingle | Claudia Interlandi Simona Di Pietro Giovanna L. Costa Filippo Spadola Nicola M. Iannelli Daniele Macrì Vincenzo Ferrantelli Francesco Macrì Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery Animals cisatracurium besylate propofol sevoflurane dog surgery |
| title | Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery |
| title_full | Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery |
| title_fullStr | Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery |
| title_full_unstemmed | Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery |
| title_short | Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery |
| title_sort | effects of cisatracurium in sevoflurane and propofol requirements in dog undergoing mastectomy surgery |
| topic | cisatracurium besylate propofol sevoflurane dog surgery |
| url | https://www.mdpi.com/2076-2615/12/22/3134 |
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