Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity
A classical view of neural coding relies on temporal firing synchrony among functional groups of neurons; however the underlying mechanism remains an enigma. Here we experimentally demonstrate a mechanism where time-lags among neuronal spiking leap from several tens of milliseconds to nearly zero-la...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00176/full |
| _version_ | 1811320072447197184 |
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| author | Roni eVardi Amir eGoldental Shoshana eGuberman Alexander eKalmanovich Hagar eMarmari Ido eKanter |
| author_facet | Roni eVardi Amir eGoldental Shoshana eGuberman Alexander eKalmanovich Hagar eMarmari Ido eKanter |
| author_sort | Roni eVardi |
| collection | DOAJ |
| description | A classical view of neural coding relies on temporal firing synchrony among functional groups of neurons; however the underlying mechanism remains an enigma. Here we experimentally demonstrate a mechanism where time-lags among neuronal spiking leap from several tens of milliseconds to nearly zero-lag synchrony. It also allows sudden leaps out of synchrony, hence forming short epochs of synchrony. Our results are based on an experimental procedure where conditioned stimulations were enforced on circuits of neurons embedded within a large-scale network of cortical cells in vitro and are corroborated by simulations of neuronal populations. The underlying biological mechanisms are the unavoidable increase of the neuronal response latency to ongoing stimulations and temporal or spatial summation required to generate evoked spikes. These sudden leaps in and out of synchrony may be accompanied by multiplications of the neuronal firing frequency, hence offering reliable information-bearing indicators which may bridge between the two principal neuronal coding paradigms. |
| first_indexed | 2024-04-13T12:53:55Z |
| format | Article |
| id | doaj.art-78d6a1b8477242f3948090b386b7558d |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-13T12:53:55Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-78d6a1b8477242f3948090b386b7558d2022-12-22T02:46:07ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102013-10-01710.3389/fncir.2013.0017665677Sudden synchrony leaps accompanied by frequency multiplications in neuronal activityRoni eVardi0Amir eGoldental1Shoshana eGuberman2Alexander eKalmanovich3Hagar eMarmari4Ido eKanter5Bar Ilan UniversityBar Ilan UniversityBar Ilan UniversityBar Ilan UniversityBar Ilan UniversityBar Ilan UniversityA classical view of neural coding relies on temporal firing synchrony among functional groups of neurons; however the underlying mechanism remains an enigma. Here we experimentally demonstrate a mechanism where time-lags among neuronal spiking leap from several tens of milliseconds to nearly zero-lag synchrony. It also allows sudden leaps out of synchrony, hence forming short epochs of synchrony. Our results are based on an experimental procedure where conditioned stimulations were enforced on circuits of neurons embedded within a large-scale network of cortical cells in vitro and are corroborated by simulations of neuronal populations. The underlying biological mechanisms are the unavoidable increase of the neuronal response latency to ongoing stimulations and temporal or spatial summation required to generate evoked spikes. These sudden leaps in and out of synchrony may be accompanied by multiplications of the neuronal firing frequency, hence offering reliable information-bearing indicators which may bridge between the two principal neuronal coding paradigms.http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00176/fullnetworktopologyneuronal circuitIn vitro modular networksfiring synchrony |
| spellingShingle | Roni eVardi Amir eGoldental Shoshana eGuberman Alexander eKalmanovich Hagar eMarmari Ido eKanter Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity Frontiers in Neural Circuits network topology neuronal circuit In vitro modular networks firing synchrony |
| title | Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity |
| title_full | Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity |
| title_fullStr | Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity |
| title_full_unstemmed | Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity |
| title_short | Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity |
| title_sort | sudden synchrony leaps accompanied by frequency multiplications in neuronal activity |
| topic | network topology neuronal circuit In vitro modular networks firing synchrony |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00176/full |
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