Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
Abstract This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.4696 |
| _version_ | 1828744401740890112 |
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| author | Yu Takeuchi Hidenao Noritake Moe Matsumoto Masahiro Umemura Maho Yamashita Kensuke Kitsugi Shingo Takatori Kazuyoshi Ohta Jun Ito Shin Shimoyama Akira Kaysuya Chiaki Maruyama Kensuke Fukuchi Satoshi Dohtan Hiroe Sakata Kazuhito Kawata |
| author_facet | Yu Takeuchi Hidenao Noritake Moe Matsumoto Masahiro Umemura Maho Yamashita Kensuke Kitsugi Shingo Takatori Kazuyoshi Ohta Jun Ito Shin Shimoyama Akira Kaysuya Chiaki Maruyama Kensuke Fukuchi Satoshi Dohtan Hiroe Sakata Kazuhito Kawata |
| author_sort | Yu Takeuchi |
| collection | DOAJ |
| description | Abstract This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction. |
| first_indexed | 2024-04-13T01:56:12Z |
| format | Article |
| id | doaj.art-78d6b69584004b4793859f246f587ab3 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-13T01:56:12Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-78d6b69584004b4793859f246f587ab32022-12-22T03:07:45ZengWileyClinical Case Reports2050-09042021-08-0198n/an/a10.1002/ccr3.4696Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case reportYu Takeuchi0Hidenao Noritake1Moe Matsumoto2Masahiro Umemura3Maho Yamashita4Kensuke Kitsugi5Shingo Takatori6Kazuyoshi Ohta7Jun Ito8Shin Shimoyama9Akira Kaysuya10Chiaki Maruyama11Kensuke Fukuchi12Satoshi Dohtan13Hiroe Sakata14Kazuhito Kawata15Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanDepartment of Dermatology Hamamatsu University School of Medicine Hamamatsu JapanDepartment of Dermatology Hamamatsu University School of Medicine Hamamatsu JapanDepartment of Dermatology Hamamatsu University School of Medicine Hamamatsu JapanDepartment of Hematology Hamamatsu University School of Medicine Hamamatsu JapanDepartment of Dentistry and Oral and Maxillofacial Surgery Hamamatsu University School of Medicine Hamamatsu JapanDivision of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu JapanAbstract This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.https://doi.org/10.1002/ccr3.4696agranulocytosisallopurinolalopeciastomatitisthiopurine |
| spellingShingle | Yu Takeuchi Hidenao Noritake Moe Matsumoto Masahiro Umemura Maho Yamashita Kensuke Kitsugi Shingo Takatori Kazuyoshi Ohta Jun Ito Shin Shimoyama Akira Kaysuya Chiaki Maruyama Kensuke Fukuchi Satoshi Dohtan Hiroe Sakata Kazuhito Kawata Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report Clinical Case Reports agranulocytosis allopurinol alopecia stomatitis thiopurine |
| title | Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report |
| title_full | Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report |
| title_fullStr | Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report |
| title_full_unstemmed | Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report |
| title_short | Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report |
| title_sort | azathioprine induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with nudt15 minor variant a case report |
| topic | agranulocytosis allopurinol alopecia stomatitis thiopurine |
| url | https://doi.org/10.1002/ccr3.4696 |
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