Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study
BackgroundObservational studies have revealed that dried fruit intake may be associated with cancer incidence; however, confounding factors make the results prone to be disturbed. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causal relationship between dried...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.899137/full |
| _version_ | 1811295894295805952 |
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| author | Chen Jin Rui Li Tuo Deng Tuo Deng Zixia Lin Zixia Lin Haoqi Li Yan Yang Qing Su Jingxian Wang Yi Yang Juejin Wang Gang Chen Gang Chen Yi Wang |
| author_facet | Chen Jin Rui Li Tuo Deng Tuo Deng Zixia Lin Zixia Lin Haoqi Li Yan Yang Qing Su Jingxian Wang Yi Yang Juejin Wang Gang Chen Gang Chen Yi Wang |
| author_sort | Chen Jin |
| collection | DOAJ |
| description | BackgroundObservational studies have revealed that dried fruit intake may be associated with cancer incidence; however, confounding factors make the results prone to be disturbed. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causal relationship between dried fruit intake and 11 site-specific cancers.Materials and methodsForty-three single nucleoside polymers (SNPs) with robust genome-wide association study (GWAS) evidence, strongly correlated with dried fruit intake, were used as instrumental variables (IVs) in this study. The summary-level genetic datasets of site-specific cancers were obtained from the Oncoarray oral cavity and oropharyngeal cancer consortium, International Lung Cancer Consortium, Breast Cancer Association Consortium (BCAC), Ovarian Cancer Association Consortium, PanScan1, and GWAS of other scholars. We analyzed the causality between dried fruit intake and 11 site-specific cancers using the inverse-variance-weighted (IVW) and weighted median (WM) methods. For the results of the MR analysis, Cochran’s Q test was used to check for heterogeneity, and multiplicative random effects were used to evaluate the heterogeneity further. Gene pleiotropy was tested using MR-Egger regression and MR-PRESSO methods. In addition, the main results of this study were validated by using the summary statistical data from the FinnGen and UK Biobank databases, and adjusted body mass index (BMI), years of education, fresh fruit intake, and vitamin C using multivariable MR analysis to ensure the stability of the research results.ResultsThe evidence from IVW analyses showed that each increase of dried fruit intake by one standard deviation was statistically significantly associated with 82.68% decrease of oral cavity/pharyngeal cancer incidence risk (P = 0.0131), 67.01% decrease of lung cancer incidence risk (P = 0.0011), 77% decrease of squamous cell lung cancer incidence risk (P = 0.0026), 53.07% decrease of breast cancer incidence risk (P = 4.62 × 10–5), 39.72% decrease of ovarian cancer incidence risk (P = 0.0183), 97.26% decrease of pancreatic cancer incidence risk (P = 0.0280), 0.53% decrease of cervical cancer incidence risk (P = 0.0482); however, there was no significant effect on lung adenocarcinoma (P = 0.4343), endometrial cancer (P = 0.8742), thyroid cancer (P = 0.6352), prostate cancer (P = 0.5354), bladder cancer (P = 0.8996), and brain cancer (P = 0.8164). In the validation part of the study results, the causal relationship between dried fruit intake and lung cancer (P = 0.0043), squamous cell lung cancer (P = 0.0136), and breast cancer (P = 0.0192) was determined. After adjusting for the potential impact of confounders, the causal relationship between dried fruit intake and lung cancer (P = 0.0034), squamous cell lung cancer (P = 0.046), and breast cancer (P = 0.0001) remained. The sensitivity analysis showed that our results were stable and reliable.ConclusionThe intake of dried fruits may have a protective effect against some site-specific cancers. Therefore, health education and a reasonable adjustment of dietary proportions may help in the primary prevention of cancer. |
| first_indexed | 2024-04-13T05:40:22Z |
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| language | English |
| last_indexed | 2024-04-13T05:40:22Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-78d85089da774c69b1f86abcfb2486602022-12-22T03:00:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-07-01910.3389/fnut.2022.899137899137Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization studyChen Jin0Rui Li1Tuo Deng2Tuo Deng3Zixia Lin4Zixia Lin5Haoqi Li6Yan Yang7Qing Su8Jingxian Wang9Yi Yang10Juejin Wang11Gang Chen12Gang Chen13Yi Wang14Department of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaBackgroundObservational studies have revealed that dried fruit intake may be associated with cancer incidence; however, confounding factors make the results prone to be disturbed. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causal relationship between dried fruit intake and 11 site-specific cancers.Materials and methodsForty-three single nucleoside polymers (SNPs) with robust genome-wide association study (GWAS) evidence, strongly correlated with dried fruit intake, were used as instrumental variables (IVs) in this study. The summary-level genetic datasets of site-specific cancers were obtained from the Oncoarray oral cavity and oropharyngeal cancer consortium, International Lung Cancer Consortium, Breast Cancer Association Consortium (BCAC), Ovarian Cancer Association Consortium, PanScan1, and GWAS of other scholars. We analyzed the causality between dried fruit intake and 11 site-specific cancers using the inverse-variance-weighted (IVW) and weighted median (WM) methods. For the results of the MR analysis, Cochran’s Q test was used to check for heterogeneity, and multiplicative random effects were used to evaluate the heterogeneity further. Gene pleiotropy was tested using MR-Egger regression and MR-PRESSO methods. In addition, the main results of this study were validated by using the summary statistical data from the FinnGen and UK Biobank databases, and adjusted body mass index (BMI), years of education, fresh fruit intake, and vitamin C using multivariable MR analysis to ensure the stability of the research results.ResultsThe evidence from IVW analyses showed that each increase of dried fruit intake by one standard deviation was statistically significantly associated with 82.68% decrease of oral cavity/pharyngeal cancer incidence risk (P = 0.0131), 67.01% decrease of lung cancer incidence risk (P = 0.0011), 77% decrease of squamous cell lung cancer incidence risk (P = 0.0026), 53.07% decrease of breast cancer incidence risk (P = 4.62 × 10–5), 39.72% decrease of ovarian cancer incidence risk (P = 0.0183), 97.26% decrease of pancreatic cancer incidence risk (P = 0.0280), 0.53% decrease of cervical cancer incidence risk (P = 0.0482); however, there was no significant effect on lung adenocarcinoma (P = 0.4343), endometrial cancer (P = 0.8742), thyroid cancer (P = 0.6352), prostate cancer (P = 0.5354), bladder cancer (P = 0.8996), and brain cancer (P = 0.8164). In the validation part of the study results, the causal relationship between dried fruit intake and lung cancer (P = 0.0043), squamous cell lung cancer (P = 0.0136), and breast cancer (P = 0.0192) was determined. After adjusting for the potential impact of confounders, the causal relationship between dried fruit intake and lung cancer (P = 0.0034), squamous cell lung cancer (P = 0.046), and breast cancer (P = 0.0001) remained. The sensitivity analysis showed that our results were stable and reliable.ConclusionThe intake of dried fruits may have a protective effect against some site-specific cancers. Therefore, health education and a reasonable adjustment of dietary proportions may help in the primary prevention of cancer.https://www.frontiersin.org/articles/10.3389/fnut.2022.899137/fulldried fruit intakesite-specific cancerscausal relationshipMendelian randomizationincidence risk |
| spellingShingle | Chen Jin Rui Li Tuo Deng Tuo Deng Zixia Lin Zixia Lin Haoqi Li Yan Yang Qing Su Jingxian Wang Yi Yang Juejin Wang Gang Chen Gang Chen Yi Wang Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study Frontiers in Nutrition dried fruit intake site-specific cancers causal relationship Mendelian randomization incidence risk |
| title | Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study |
| title_full | Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study |
| title_fullStr | Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study |
| title_full_unstemmed | Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study |
| title_short | Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study |
| title_sort | association between dried fruit intake and pan cancers incidence risk a two sample mendelian randomization study |
| topic | dried fruit intake site-specific cancers causal relationship Mendelian randomization incidence risk |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.899137/full |
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