Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats
Aim: Barbigerone is a natural pyranoisoflavone having antioxidant potential. The current research was aimed to study the anti-diabetic role of barbigerone on streptozotocin-induced experimental rats. Material & methods: To perform the anti-diabetic activity, the animals were segregated into...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S101836472200430X |
| _version_ | 1828237409466187776 |
|---|---|
| author | Fahad A. Al-Abbasi |
| author_facet | Fahad A. Al-Abbasi |
| author_sort | Fahad A. Al-Abbasi |
| collection | DOAJ |
| description | Aim: Barbigerone is a natural pyranoisoflavone having antioxidant potential. The current research was aimed to study the anti-diabetic role of barbigerone on streptozotocin-induced experimental rats. Material & methods: To perform the anti-diabetic activity, the animals were segregated into four groups: Group 1- Control (5 ml/kg saline), Group 2- Streptozotocin control (60 mg/kg i.p.), Group 3 and 4 - Barbigerone (10 and 20 mg/kg, respectively). Results: Both the doses showed a beneficial effect on all the parameters assessed. The effect was better pronounced by 20 mg/kg than 10 mg/kg. Barbigerone showed a protective effect on blood glucose, lipid profile, antioxidant, liver enzymes, and inflammatory cytokines. It suggested that barbigerone displayed lipid-lowering action and antiperoxidative effect in streptozotocin-activated diabetic animals. Conclusion: The outcome of this work reflects that 20 mg/kg barbigerone is more potent and produced ameliorative effects in streptozotocin-induced rats. |
| first_indexed | 2024-04-12T20:48:09Z |
| format | Article |
| id | doaj.art-78d90cede7294ffdb76b20189ba8ba26 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-12T20:48:09Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-78d90cede7294ffdb76b20189ba8ba262022-12-22T03:17:12ZengElsevierJournal of King Saud University: Science1018-36472022-10-01347102249Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic ratsFahad A. Al-Abbasi0Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaAim: Barbigerone is a natural pyranoisoflavone having antioxidant potential. The current research was aimed to study the anti-diabetic role of barbigerone on streptozotocin-induced experimental rats. Material & methods: To perform the anti-diabetic activity, the animals were segregated into four groups: Group 1- Control (5 ml/kg saline), Group 2- Streptozotocin control (60 mg/kg i.p.), Group 3 and 4 - Barbigerone (10 and 20 mg/kg, respectively). Results: Both the doses showed a beneficial effect on all the parameters assessed. The effect was better pronounced by 20 mg/kg than 10 mg/kg. Barbigerone showed a protective effect on blood glucose, lipid profile, antioxidant, liver enzymes, and inflammatory cytokines. It suggested that barbigerone displayed lipid-lowering action and antiperoxidative effect in streptozotocin-activated diabetic animals. Conclusion: The outcome of this work reflects that 20 mg/kg barbigerone is more potent and produced ameliorative effects in streptozotocin-induced rats.http://www.sciencedirect.com/science/article/pii/S101836472200430XAnti-diabeticAntihyperlipidemicBarbigeroneDiabetes mellitusStreptozotocin |
| spellingShingle | Fahad A. Al-Abbasi Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats Journal of King Saud University: Science Anti-diabetic Antihyperlipidemic Barbigerone Diabetes mellitus Streptozotocin |
| title | Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats |
| title_full | Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats |
| title_fullStr | Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats |
| title_full_unstemmed | Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats |
| title_short | Potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats |
| title_sort | potential antidiabetic activity of barbigerone on glucose and inflammatory cytokine levels in streptozotocin activated diabetic rats |
| topic | Anti-diabetic Antihyperlipidemic Barbigerone Diabetes mellitus Streptozotocin |
| url | http://www.sciencedirect.com/science/article/pii/S101836472200430X |
| work_keys_str_mv | AT fahadaalabbasi potentialantidiabeticactivityofbarbigeroneonglucoseandinflammatorycytokinelevelsinstreptozotocinactivateddiabeticrats |