CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors
Photothermal therapy is an efficient cancer treatment method. The development of nanoagents with high biocompatibility and a near-infrared (NIR) photoabsorption band is a prerequisite to the success of this method. However, the therapeutic efficiency of photothermal therapy is rather limited because...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmats.2020.00289/full |
| _version_ | 1819118698027286528 |
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| author | Shan Huang Gang Li Zhengyuan Yang Min Hua Zhe Yuan Xin Jin |
| author_facet | Shan Huang Gang Li Zhengyuan Yang Min Hua Zhe Yuan Xin Jin |
| author_sort | Shan Huang |
| collection | DOAJ |
| description | Photothermal therapy is an efficient cancer treatment method. The development of nanoagents with high biocompatibility and a near-infrared (NIR) photoabsorption band is a prerequisite to the success of this method. However, the therapeutic efficiency of photothermal therapy is rather limited because most nanoagents have a low photothermal conversion efficiency. In this study, we aimed to develop CuFeS2 nanoassemblies with an excellent photothermal effect using the liquid-solid-solution method. The CuFeS2 nanoassemblies we developed are composed of ultrasmall CuFeS2 nanoparticles with an average size of 5 nm, which have strong NIR photoabsorption. Under NIR laser illumination at 808 nm at the output power intensity of 1.0 W cm–2, the CuFeS2 nanoassemblies could rapidly convert NIR light into heat, achieving a high photothermal conversion efficiency of 46.8%. When K7M2 cells were incubated with the CuFeS2 nanoassemblies and then exposed to irradiation, their viability decreased progressively as the concentration of the CuFeS2 nanoassemblies increased. Furthermore, a concentration of 40 ppm of CuFeS2 nanoassemblies was lethal to the cells. Importantly, after an intratumoral injection of 40 ppm of CuFeS2 nanoassemblies, the tumor showed a high contrast in the thermal image after laser irradiation, and tumor cells with condensed nuclei and a loss of cell morphology could be thermally ablated. Therefore, the CuFeS2 nanoassemblies we synthesized have a high biocompatibility and robust photothermal effect and can, thus, be utilized as a novel and efficient photothermal agent for tumor therapy. |
| first_indexed | 2024-12-22T05:53:00Z |
| format | Article |
| id | doaj.art-78d97f30d88b48e594e05ce45992745f |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-22T05:53:00Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-78d97f30d88b48e594e05ce45992745f2022-12-21T18:36:49ZengFrontiers Media S.A.Frontiers in Materials2296-80162020-09-01710.3389/fmats.2020.00289571603CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of TumorsShan Huang0Gang Li1Zhengyuan Yang2Min Hua3Zhe Yuan4Xin Jin5College of Engineering, Zhejiang Normal University, Jinhua, ChinaSchool of Mechanical Engineering, Hubei University of Arts and Science, Xiangyang, ChinaCollege of Engineering, Zhejiang Normal University, Jinhua, ChinaUSC-SJTU Institute of Cultural and Creative Industry, Shanghai Jiao Tong University, Shanghai, ChinaXingzhi College, Zhejiang Normal University, Jinhua, ChinaDepartment of Orthopedics, Shengli Oilfield Central Hospital, Dongying, ChinaPhotothermal therapy is an efficient cancer treatment method. The development of nanoagents with high biocompatibility and a near-infrared (NIR) photoabsorption band is a prerequisite to the success of this method. However, the therapeutic efficiency of photothermal therapy is rather limited because most nanoagents have a low photothermal conversion efficiency. In this study, we aimed to develop CuFeS2 nanoassemblies with an excellent photothermal effect using the liquid-solid-solution method. The CuFeS2 nanoassemblies we developed are composed of ultrasmall CuFeS2 nanoparticles with an average size of 5 nm, which have strong NIR photoabsorption. Under NIR laser illumination at 808 nm at the output power intensity of 1.0 W cm–2, the CuFeS2 nanoassemblies could rapidly convert NIR light into heat, achieving a high photothermal conversion efficiency of 46.8%. When K7M2 cells were incubated with the CuFeS2 nanoassemblies and then exposed to irradiation, their viability decreased progressively as the concentration of the CuFeS2 nanoassemblies increased. Furthermore, a concentration of 40 ppm of CuFeS2 nanoassemblies was lethal to the cells. Importantly, after an intratumoral injection of 40 ppm of CuFeS2 nanoassemblies, the tumor showed a high contrast in the thermal image after laser irradiation, and tumor cells with condensed nuclei and a loss of cell morphology could be thermally ablated. Therefore, the CuFeS2 nanoassemblies we synthesized have a high biocompatibility and robust photothermal effect and can, thus, be utilized as a novel and efficient photothermal agent for tumor therapy.https://www.frontiersin.org/article/10.3389/fmats.2020.00289/fullnear infrared lightbioimagingphotothermal conversionCuFeS2 nanoassembliescancer therapy |
| spellingShingle | Shan Huang Gang Li Zhengyuan Yang Min Hua Zhe Yuan Xin Jin CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors Frontiers in Materials near infrared light bioimaging photothermal conversion CuFeS2 nanoassemblies cancer therapy |
| title | CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors |
| title_full | CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors |
| title_fullStr | CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors |
| title_full_unstemmed | CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors |
| title_short | CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors |
| title_sort | cufes2 nanoassemblies with intense near infrared absorbance for photothermal therapy of tumors |
| topic | near infrared light bioimaging photothermal conversion CuFeS2 nanoassemblies cancer therapy |
| url | https://www.frontiersin.org/article/10.3389/fmats.2020.00289/full |
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