Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
Abstract Background The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critica...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01410-z |
| _version_ | 1798006397154099200 |
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| author | Hong Sang Choi Ansuja Pulickal Mathew Saji Uthaman Arathy Vasukutty In Jin Kim Sang Heon Suh Chang Seong Kim Seong Kwon Ma Sontyana Adonijah Graham Soo Wan Kim In-Kyu Park Eun Hui Bae |
| author_facet | Hong Sang Choi Ansuja Pulickal Mathew Saji Uthaman Arathy Vasukutty In Jin Kim Sang Heon Suh Chang Seong Kim Seong Kwon Ma Sontyana Adonijah Graham Soo Wan Kim In-Kyu Park Eun Hui Bae |
| author_sort | Hong Sang Choi |
| collection | DOAJ |
| description | Abstract Background The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critically contributes to the progression of chronic kidney disease and finally, end-stage renal disease. Thus, delivering therapeutic agents to the ROS-rich inflammation site and releasing the therapeutic agents is a feasible solution. Results We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Hydrophobic dMn3O4 nanoparticles were loaded inside PTC micelles to prevent premature release during circulation and act as a therapeutic agent by ROS-responsive release of loaded dMn3O4 once it reached the inflammation site. Conclusions The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases. Graphical Abstract |
| first_indexed | 2024-04-11T12:55:20Z |
| format | Article |
| id | doaj.art-78da0b04a25f462ca4d46274ee52d0ef |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T12:55:20Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-78da0b04a25f462ca4d46274ee52d0ef2022-12-22T04:23:06ZengBMCJournal of Nanobiotechnology1477-31552022-04-0120112110.1186/s12951-022-01410-zInflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stressHong Sang Choi0Ansuja Pulickal Mathew1Saji Uthaman2Arathy Vasukutty3In Jin Kim4Sang Heon Suh5Chang Seong Kim6Seong Kwon Ma7Sontyana Adonijah Graham8Soo Wan Kim9In-Kyu Park10Eun Hui Bae11Departments of Internal Medicine, Chonnam National University Medical SchoolDepartment of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical SchoolDepartment of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical SchoolDepartment of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University HospitalDepartments of Internal Medicine, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University Medical SchoolDepartment of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University Medical SchoolDepartment of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University Medical SchoolAbstract Background The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critically contributes to the progression of chronic kidney disease and finally, end-stage renal disease. Thus, delivering therapeutic agents to the ROS-rich inflammation site and releasing the therapeutic agents is a feasible solution. Results We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Hydrophobic dMn3O4 nanoparticles were loaded inside PTC micelles to prevent premature release during circulation and act as a therapeutic agent by ROS-responsive release of loaded dMn3O4 once it reached the inflammation site. Conclusions The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01410-zMn3O4 nanoparticlesNanozymesInflammationIschemia–reperfusionKidney |
| spellingShingle | Hong Sang Choi Ansuja Pulickal Mathew Saji Uthaman Arathy Vasukutty In Jin Kim Sang Heon Suh Chang Seong Kim Seong Kwon Ma Sontyana Adonijah Graham Soo Wan Kim In-Kyu Park Eun Hui Bae Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress Journal of Nanobiotechnology Mn3O4 nanoparticles Nanozymes Inflammation Ischemia–reperfusion Kidney |
| title | Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress |
| title_full | Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress |
| title_fullStr | Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress |
| title_full_unstemmed | Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress |
| title_short | Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress |
| title_sort | inflammation sensing catalase mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress |
| topic | Mn3O4 nanoparticles Nanozymes Inflammation Ischemia–reperfusion Kidney |
| url | https://doi.org/10.1186/s12951-022-01410-z |
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