Multifrequency-based sharpening of focal volume
Abstract Systems that emit electromagnetic or sonic waves for diagnostic or interventional applications often have constraints on the size of their aperture, and thus produce an elongated focus in the axial dimension. This extended depth of focus limits imaging resolution and spatial specificity of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25886-9 |
| _version_ | 1797977477516099584 |
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| author | Thomas Riis Jan Kubanek |
| author_facet | Thomas Riis Jan Kubanek |
| author_sort | Thomas Riis |
| collection | DOAJ |
| description | Abstract Systems that emit electromagnetic or sonic waves for diagnostic or interventional applications often have constraints on the size of their aperture, and thus produce an elongated focus in the axial dimension. This extended depth of focus limits imaging resolution and spatial specificity of the delivered energy. Here, we have developed a method that substantially minimizes the depth of focus. The method superimposes beams of distinct frequencies in space and time to create constructive interference at target and amplify deconstructive interference everywhere else, thus sharpening the focus. The method does not require labeling of targets or other manipulations of the medium. Using simulations, we found that the method tightens the depth of focus even for systems with a narrow bandwidth. Moreover, we implemented the method in ultrasonic hardware and found that a 46.1% frequency fractional bandwidth provides an average 7.4-fold reduction in the focal volume of the resulting beams. This method can be readily applied to sharpen the focus of interventional systems and is expected to also improve the axial resolution of existing imaging systems. |
| first_indexed | 2024-04-11T05:07:34Z |
| format | Article |
| id | doaj.art-78da7100a483481191a94f7644d35638 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T05:07:34Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-78da7100a483481191a94f7644d356382022-12-25T12:13:24ZengNature PortfolioScientific Reports2045-23222022-12-011211810.1038/s41598-022-25886-9Multifrequency-based sharpening of focal volumeThomas Riis0Jan Kubanek1Department of Biomedical Engineering, University of UtahDepartment of Biomedical Engineering, University of UtahAbstract Systems that emit electromagnetic or sonic waves for diagnostic or interventional applications often have constraints on the size of their aperture, and thus produce an elongated focus in the axial dimension. This extended depth of focus limits imaging resolution and spatial specificity of the delivered energy. Here, we have developed a method that substantially minimizes the depth of focus. The method superimposes beams of distinct frequencies in space and time to create constructive interference at target and amplify deconstructive interference everywhere else, thus sharpening the focus. The method does not require labeling of targets or other manipulations of the medium. Using simulations, we found that the method tightens the depth of focus even for systems with a narrow bandwidth. Moreover, we implemented the method in ultrasonic hardware and found that a 46.1% frequency fractional bandwidth provides an average 7.4-fold reduction in the focal volume of the resulting beams. This method can be readily applied to sharpen the focus of interventional systems and is expected to also improve the axial resolution of existing imaging systems.https://doi.org/10.1038/s41598-022-25886-9 |
| spellingShingle | Thomas Riis Jan Kubanek Multifrequency-based sharpening of focal volume Scientific Reports |
| title | Multifrequency-based sharpening of focal volume |
| title_full | Multifrequency-based sharpening of focal volume |
| title_fullStr | Multifrequency-based sharpening of focal volume |
| title_full_unstemmed | Multifrequency-based sharpening of focal volume |
| title_short | Multifrequency-based sharpening of focal volume |
| title_sort | multifrequency based sharpening of focal volume |
| url | https://doi.org/10.1038/s41598-022-25886-9 |
| work_keys_str_mv | AT thomasriis multifrequencybasedsharpeningoffocalvolume AT jankubanek multifrequencybasedsharpeningoffocalvolume |