Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury
(1) Background: When the body is exposed to microwave radiation, the brain is more susceptible to damage than other organs. However, few effective drugs are available for the treatment of microwave-induced brain injury (MIBI) because most drugs are difficult to cross the blood–brain barrier (BBB) to...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/2/108 |
| _version_ | 1797480000771850240 |
|---|---|
| author | Yuanyuan Zhang Qian Li Jinglu Hu Chunqing Wang Delian Wan Qi Li Qingwei Jiang Lina Du Yiguang Jin |
| author_facet | Yuanyuan Zhang Qian Li Jinglu Hu Chunqing Wang Delian Wan Qi Li Qingwei Jiang Lina Du Yiguang Jin |
| author_sort | Yuanyuan Zhang |
| collection | DOAJ |
| description | (1) Background: When the body is exposed to microwave radiation, the brain is more susceptible to damage than other organs. However, few effective drugs are available for the treatment of microwave-induced brain injury (MIBI) because most drugs are difficult to cross the blood–brain barrier (BBB) to reach the brain. (2) Methods: Nasal cinnarizine inclusion complexes with thermo-and ion-sensitive hydrogels (cinnarizine ISGs) were prepared to treat MIBI and the characteristics of the inclusion complexes and their thermo-and ion-sensitive hydrogels were evaluated. (3) Results: Due to high viscosity, cinnarizine ISGs can achieve long-term retention in the nasal cavity to achieve a sustained release effect. Compared with the model, the intranasal thermo-and ion-sensitive cinnarizine ISGs significantly improved the microwave-induced spatial memory and spontaneous exploration behavior with Morris water maze and open field tests. Cinnarizine ISGs inhibited the expression of calcineurin and calpain 1 in the brain, which may be related to the inhibition of calcium overload by cinnarizine. (4) Conclusion: Intranasal thermo- and ion-sensitive cinnarizine ISGs are a promising brain-targeted pharmaceutical preparation against MIBI. |
| first_indexed | 2024-03-09T21:53:50Z |
| format | Article |
| id | doaj.art-78dafa81cd604db2ae028ece65be13f2 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T21:53:50Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-78dafa81cd604db2ae028ece65be13f22023-11-23T20:01:55ZengMDPI AGGels2310-28612022-02-018210810.3390/gels8020108Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain InjuryYuanyuan Zhang0Qian Li1Jinglu Hu2Chunqing Wang3Delian Wan4Qi Li5Qingwei Jiang6Lina Du7Yiguang Jin8School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaKey Laboratory of Natural Medicine of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China(1) Background: When the body is exposed to microwave radiation, the brain is more susceptible to damage than other organs. However, few effective drugs are available for the treatment of microwave-induced brain injury (MIBI) because most drugs are difficult to cross the blood–brain barrier (BBB) to reach the brain. (2) Methods: Nasal cinnarizine inclusion complexes with thermo-and ion-sensitive hydrogels (cinnarizine ISGs) were prepared to treat MIBI and the characteristics of the inclusion complexes and their thermo-and ion-sensitive hydrogels were evaluated. (3) Results: Due to high viscosity, cinnarizine ISGs can achieve long-term retention in the nasal cavity to achieve a sustained release effect. Compared with the model, the intranasal thermo-and ion-sensitive cinnarizine ISGs significantly improved the microwave-induced spatial memory and spontaneous exploration behavior with Morris water maze and open field tests. Cinnarizine ISGs inhibited the expression of calcineurin and calpain 1 in the brain, which may be related to the inhibition of calcium overload by cinnarizine. (4) Conclusion: Intranasal thermo- and ion-sensitive cinnarizine ISGs are a promising brain-targeted pharmaceutical preparation against MIBI.https://www.mdpi.com/2310-2861/8/2/108microwave-induced brain injury (MIBI)cinnarizinesulfobutyl-β-cyclodextrininclusion complexthermo- and ion-sensitive hydrogelsbrain targeting |
| spellingShingle | Yuanyuan Zhang Qian Li Jinglu Hu Chunqing Wang Delian Wan Qi Li Qingwei Jiang Lina Du Yiguang Jin Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury Gels microwave-induced brain injury (MIBI) cinnarizine sulfobutyl-β-cyclodextrin inclusion complex thermo- and ion-sensitive hydrogels brain targeting |
| title | Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury |
| title_full | Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury |
| title_fullStr | Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury |
| title_full_unstemmed | Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury |
| title_short | Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury |
| title_sort | nasal delivery of cinnarizine thermo and ion sensitive in situ hydrogels for treatment of microwave induced brain injury |
| topic | microwave-induced brain injury (MIBI) cinnarizine sulfobutyl-β-cyclodextrin inclusion complex thermo- and ion-sensitive hydrogels brain targeting |
| url | https://www.mdpi.com/2310-2861/8/2/108 |
| work_keys_str_mv | AT yuanyuanzhang nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT qianli nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT jingluhu nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT chunqingwang nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT delianwan nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT qili nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT qingweijiang nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT linadu nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury AT yiguangjin nasaldeliveryofcinnarizinethermoandionsensitiveinsituhydrogelsfortreatmentofmicrowaveinducedbraininjury |