Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients

Background. Cardiovascular autonomic neuropathy (CAN) is a severely debilitating yet underdiagnosed condition in patients with diabetes mellitus. The prevalence can range from 2.5 % (based on the primary prevention cohort in the Diabetes Control and Complications Trial) to as high as 90 % of diabeti...

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Main Authors: Sanjay Kumar, Satyanath Reddy Kodidala, Srinivasa Jayachandra
Format: Article
Language:English
Published: Zaslavsky O.Yu. 2022-03-01
Series:Mìžnarodnij Endokrinologìčnij Žurnal
Subjects:
Online Access:https://iej.zaslavsky.com.ua/index.php/journal/article/view/1140
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author Sanjay Kumar
Satyanath Reddy Kodidala
Srinivasa Jayachandra
author_facet Sanjay Kumar
Satyanath Reddy Kodidala
Srinivasa Jayachandra
author_sort Sanjay Kumar
collection DOAJ
description Background. Cardiovascular autonomic neuropathy (CAN) is a severely debilitating yet underdiagnosed condition in patients with diabetes mellitus. The prevalence can range from 2.5 % (based on the primary prevention cohort in the Diabetes Control and Complications Trial) to as high as 90 % of diabetic patients. Clinical manifestations range from orthostasis to myocardial infarction. The diagnosis is made using multiple autonomic function tests to assess both sympathetic and parasympathetic function. This study was conducted to assess the relationship between Cardiac autonomic neuropathy and QT interval. Material and methods. This was a cross-sectional study conducted in 100 patients attending a tertiary care hospital in India. Deep breathing test, Valsalva ratio, immediate heart rate response to standing 30 : 15, BP rise with sustained hand grip and postural hypotension were evaluated. Scoring was done for cardiac autonomic neuropathy. QT interval and QTc interval were determined and association with CAN was obtained. Results. Out of 100 type 2 diabetic patients, 60 % were males and 40 % were females. 25 patients having no cardiac autonomic neuropathy and had no prolonged QTc interval. While, 75 patients had QTc prolonged were associated with early and severe CAN cardiac autonomic neuropathy. The prolonged QTc was significantly associated with CAN in diabetic patients when compared without CAN and controls (P < 0.0001). The grading score for CAD showed that 75 % cases were having score > 2 were 25 % of cases had score < 2. Out of 75 patients 44 were between score 2–4 and 31 were above score 4. A significant association between QTc and Diabetic CAN patients observed when compared non CAN and controls. Conclusions. Diabetic cardiac autonomic neuropathy is associated with increase in prolongation of QTc intervals. Hence, there is need for regular checkup of autonomic nervous system in diabetic patient to prevent further complications.
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spelling doaj.art-78dc94182c424f15a9e5f3f078ff6f2c2023-04-02T18:33:11ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272022-03-01181121610.22141/2224-0721.18.1.2022.11401140Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patientsSanjay Kumar0https://orcid.org/0000-0002-9113-3428Satyanath Reddy Kodidala1https://orcid.org/0000-0001-7830-7211Srinivasa Jayachandra2https://orcid.org/0000-0001-9473-8011Zydus Medical College and Hospital, Dahod, Gujarat, IndiaZydus Medical College and Hospital, Dahod, Gujarat, IndiaZydus Medical College and Hospital, Dahod, Gujarat, IndiaBackground. Cardiovascular autonomic neuropathy (CAN) is a severely debilitating yet underdiagnosed condition in patients with diabetes mellitus. The prevalence can range from 2.5 % (based on the primary prevention cohort in the Diabetes Control and Complications Trial) to as high as 90 % of diabetic patients. Clinical manifestations range from orthostasis to myocardial infarction. The diagnosis is made using multiple autonomic function tests to assess both sympathetic and parasympathetic function. This study was conducted to assess the relationship between Cardiac autonomic neuropathy and QT interval. Material and methods. This was a cross-sectional study conducted in 100 patients attending a tertiary care hospital in India. Deep breathing test, Valsalva ratio, immediate heart rate response to standing 30 : 15, BP rise with sustained hand grip and postural hypotension were evaluated. Scoring was done for cardiac autonomic neuropathy. QT interval and QTc interval were determined and association with CAN was obtained. Results. Out of 100 type 2 diabetic patients, 60 % were males and 40 % were females. 25 patients having no cardiac autonomic neuropathy and had no prolonged QTc interval. While, 75 patients had QTc prolonged were associated with early and severe CAN cardiac autonomic neuropathy. The prolonged QTc was significantly associated with CAN in diabetic patients when compared without CAN and controls (P < 0.0001). The grading score for CAD showed that 75 % cases were having score > 2 were 25 % of cases had score < 2. Out of 75 patients 44 were between score 2–4 and 31 were above score 4. A significant association between QTc and Diabetic CAN patients observed when compared non CAN and controls. Conclusions. Diabetic cardiac autonomic neuropathy is associated with increase in prolongation of QTc intervals. Hence, there is need for regular checkup of autonomic nervous system in diabetic patient to prevent further complications.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1140type 2 diabetes mellituscardiac autonomic neuropathyecgqtc interval
spellingShingle Sanjay Kumar
Satyanath Reddy Kodidala
Srinivasa Jayachandra
Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients
Mìžnarodnij Endokrinologìčnij Žurnal
type 2 diabetes mellitus
cardiac autonomic neuropathy
ecg
qtc interval
title Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients
title_full Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients
title_fullStr Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients
title_full_unstemmed Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients
title_short Retracted: Association of QT interval indices with cardiac autonomic neuropathy in diabetic patients
title_sort retracted association of qt interval indices with cardiac autonomic neuropathy in diabetic patients
topic type 2 diabetes mellitus
cardiac autonomic neuropathy
ecg
qtc interval
url https://iej.zaslavsky.com.ua/index.php/journal/article/view/1140
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AT satyanathreddykodidala retractedassociationofqtintervalindiceswithcardiacautonomicneuropathyindiabeticpatients
AT srinivasajayachandra retractedassociationofqtintervalindiceswithcardiacautonomicneuropathyindiabeticpatients