Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer and the third leading cause of cancer-related deaths worldwide. A substantial body of literature supports the crucial role of vitamin D (VD) in the etiology, progression, prognosis, and treatment of cancer. Recent clinical studies...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/2310-2861/9/7/561 |
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| author | Ozlem Bingol Ozakpinar Havva Dastan Merve Gurboga Fatih Serdar Sayin Derya Ozsavci Elif Caliskan Salihi |
| author_facet | Ozlem Bingol Ozakpinar Havva Dastan Merve Gurboga Fatih Serdar Sayin Derya Ozsavci Elif Caliskan Salihi |
| author_sort | Ozlem Bingol Ozakpinar |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer and the third leading cause of cancer-related deaths worldwide. A substantial body of literature supports the crucial role of vitamin D (VD) in the etiology, progression, prognosis, and treatment of cancer. Recent clinical studies have found an inverse correlation between CRC incidence and serum VD levels. However, the low water solubility of VD and its anticarcinogenic activity at supraphysiological plasma levels, which causes hypercalcemia, required carrier systems. Carbon-based nanomaterials are excellent eco-friendly candidates, with exceptional chemical resistance, efficient mechanical properties, and negligible weight. Furthermore, composite aerogels manufactured from these nanomaterials have gained interest due to their extensive surface areas and porous structures, which make them suitable for delivering drugs. Our research aimed to study the development of composite aerogels loaded with VD by utilizing carbon nanofibers (CNFs) in an aerogel matrix provided to colon cancer cells. For this purpose, Aero1 as a drug delivery system was first prepared and characterized using XRD, FTIR, and SEM methods. Biochemical methods were employed to evaluate the antiproliferative, apoptotic, and anti-migratory effects on colon cancer cells. FTIR and XRD measurements confirmed the production of aerogels. SEM analysis revealed that aerogels have a non-uniform surface. The findings showed that aerogels can effectively deliver VD to the colon cancer cells, while also inhibiting cancer cell proliferation and migration. This research suggests that the Aero1 drug delivery system could be a valuable tool in the fight against colon cancer and other health issues. |
| first_indexed | 2024-03-11T01:02:43Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T01:02:43Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Gels |
| spelling | doaj.art-78dd6b66ee4d42bcb17e747f458d76922023-11-18T19:27:56ZengMDPI AGGels2310-28612023-07-019756110.3390/gels9070561Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer CellsOzlem Bingol Ozakpinar0Havva Dastan1Merve Gurboga2Fatih Serdar Sayin3Derya Ozsavci4Elif Caliskan Salihi5Department of Biochemistry, Faculty of Pharmacy, Marmara University, 34854 Istanbul, TurkeyDepartment of Biochemistry, Health Sciences Institute, Marmara University, 34865 Istanbul, TurkeyDepartment of Biochemistry, Health Sciences Institute, Marmara University, 34865 Istanbul, TurkeyDepartment of Electrical-Electronics Engineering, Faculty of Technology, Marmara University, 34840 Istanbul, TurkeyDepartment of Biochemistry, Faculty of Pharmacy, Marmara University, 34854 Istanbul, TurkeyDepartment of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Marmara University, 34854 Istanbul, TurkeyColorectal cancer (CRC) is the fourth most commonly diagnosed cancer and the third leading cause of cancer-related deaths worldwide. A substantial body of literature supports the crucial role of vitamin D (VD) in the etiology, progression, prognosis, and treatment of cancer. Recent clinical studies have found an inverse correlation between CRC incidence and serum VD levels. However, the low water solubility of VD and its anticarcinogenic activity at supraphysiological plasma levels, which causes hypercalcemia, required carrier systems. Carbon-based nanomaterials are excellent eco-friendly candidates, with exceptional chemical resistance, efficient mechanical properties, and negligible weight. Furthermore, composite aerogels manufactured from these nanomaterials have gained interest due to their extensive surface areas and porous structures, which make them suitable for delivering drugs. Our research aimed to study the development of composite aerogels loaded with VD by utilizing carbon nanofibers (CNFs) in an aerogel matrix provided to colon cancer cells. For this purpose, Aero1 as a drug delivery system was first prepared and characterized using XRD, FTIR, and SEM methods. Biochemical methods were employed to evaluate the antiproliferative, apoptotic, and anti-migratory effects on colon cancer cells. FTIR and XRD measurements confirmed the production of aerogels. SEM analysis revealed that aerogels have a non-uniform surface. The findings showed that aerogels can effectively deliver VD to the colon cancer cells, while also inhibiting cancer cell proliferation and migration. This research suggests that the Aero1 drug delivery system could be a valuable tool in the fight against colon cancer and other health issues.https://www.mdpi.com/2310-2861/9/7/561vitamin Ddrug delivery systemcarbon nanofiberaerogelcolon cancer cellsapoptosis |
| spellingShingle | Ozlem Bingol Ozakpinar Havva Dastan Merve Gurboga Fatih Serdar Sayin Derya Ozsavci Elif Caliskan Salihi Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells Gels vitamin D drug delivery system carbon nanofiber aerogel colon cancer cells apoptosis |
| title | Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells |
| title_full | Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells |
| title_fullStr | Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells |
| title_full_unstemmed | Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells |
| title_short | Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells |
| title_sort | carbon nanofiber sodium alginate composite aerogels loaded with vitamin d the cytotoxic and apoptotic effects on colon cancer cells |
| topic | vitamin D drug delivery system carbon nanofiber aerogel colon cancer cells apoptosis |
| url | https://www.mdpi.com/2310-2861/9/7/561 |
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